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Host Defense > B-cell Immunity > Flashcards

B-cell Immunity Flashcards

1
Q 
Give 6 properties of B-1 cells?
V-region Repertoire
Location 
Requirement for T cell
Memory 
VDJ rearrangement 
Isotype switch
A 
restricted v-region repertoire
body cavities(peritoneal, pleural)-don't find them in blood 
no tcell help
no memory development
do VDJ rearrangement 
no isotype switch 
-
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2
Q 
Give 4 properties of B-1 cells?
V-region Repertoire
Location 
Requirement for T cell
Memory
A

restricted v-region repertoire
body cavities(peritoneal, pleural)
no tcell help
no memory development

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3
Q

Where are marginal zone B-cells located?

A

Spleen-at the interface of circulation and lymphoid tissue

properties like B-1 cells

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4
Q

How does size, route, similiarity to self protein, adjuvants affect immunogenicity?

A 
Better-->worse 
Large-->small
Subcutaneous, intraperitoneal, intravenous or intragastric
Multiple differences-->few
slow release--> rapid release
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5
Q

What is a common adjuvant?

A

alum

composition: aluminum hydroxide gel
- delayed release of antigen; enhanced macrophage uptake

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6
Q

What two signals do B-cells (conventional B-2 cells) need to be activated?

A
  1. IgM takes up antigen and presents it on the surface (MHC class 2)
  2. t cells recognize this antigen and stimulate cytokines which cause b-cell to proliferate and differentiate into antibody producing cells (plasma cells)

For T-dependent responses, these two signals are:
1)interaction of BCR with antigen; 2) interaction of TCR with peptide/MHC complex and interaction
between costimulatory molecules CD40 (B cell) and CD40L (T cell).

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7
Q

Do carbs need t-cell help?

A

No

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8
Q

How do babies make anti-carb antibody(cant make T-independent response to polysaccharides)?

A
  1. add tetanus protein to carb
  2. b cell recognizes the the tetanus
  3. internalizes it and presents it to t-cell
  4. t-cell activates bcell
  5. b-cell produces antibody against polysaccharide antigen on the surface of bacterium
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9
Q

Affinity increases in secondary responses because of what?

A

somatic hypermutation

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10
Q

What enzyme is responsible for isotype switch?

A

AID

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11
Q

What happens in the germinal center?

A
  1. Somatic hypermutation
  2. class switch recombination
  3. development of memory b-cells
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12
Q

What happens in the dark zone of the germinal center?

A
  1. somatic hypermutation
    - happens primarily in the sequence of vdj genes–binding sites-capacity to bind antigen with high affinity
  2. class switch
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13
Q

What is in the light zone?

A

follicular dendritic cells

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14
Q

How are b-cells that underwent somatic hypermutaiton selected?

A

Positive selection

  • must have high-affinity surface immunoglobulin
  • if they have BCR cross linking and T-cell help they can mature and proliferate
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15
Q

Where do the B-cells get the antigen from?

A

from the follicular dendritic cells

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16
Q

How do antibody response to Ti Antigen?(polysaccharide)

A

No germinal center
no somatic mutation
no memory
no isotype switch-IgM

17
Q

What 2 types of arrangements are Somatic DNA Rearrangements?

A

VDJ rearrangement-mediated by RSS and RAGR1/RAG2

Isotype switch-by AID

18
Q

When does isotype switch occur?

A

During T-dependent responses and is regulated by T-cell cytokines

19
Q

What are geminal centers sites for?

A

B cell proliferation and differentiation

20
Q

When do germianl centers form?

A

during immune responses

  • isotype switch
  • somatic hypermutaiton
  • development of memory bcells
21
Q

What happens after hypermutation?

A

cells with high affinity receptors are rescued from cell dealth by antigen in the form of antigen-antibody complexes bound to follicular dendritic cells followed by B-cell presentation of the antigen to Thelper cells

22
Q

What happens after hypermutation?

A

cells with high affinity receptors are rescued from cell death by antigen in the form of antigen-antibody complexes bound to follicular dendritic cells followed by B-cell presentation of the antigen to Thelper cells

23
Q

Are the antigens that trigger t-indepenedent b-cells comprised of repetitive units which triggers cross linking of the BCR?

A

yes

Host Defense (11 decks)

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