Immunodeficiencies

Question 1

What are primary immunodeficiciency disorders PIDs

Answer 1

rare, intriisnic, usually inherited immune disorder resulting from geentic mutations (usually present at birth and diagnosed in childhood)

Question 2

What are secondary immunodeficiency disorder? SIDS

Answer 2

acquired immunodeficiency as a reusult of disease or environemental factors

(HIv, steriods, mlaignnacy,lymphomas)

Question 3

are PIDs more common in males ore females?

Answer 3

More common in males (2:1), as many disorder follow X linked pattern

1/1,2000-20,000 births

Question 4

which component of the immune system are moslty affected by PIDs

Answer 4

Antibodies

(result in extracellular bacterial infections)

wheras if you had T cell deficineices0- more suscpetibelt on itnracellular infections-n virus

Question 5

what are some common causes of SIDS (4 categories)

Answer 5

• Malnutrition- biggest global cause
• drug effect
  
  • chemotherpay
  • immunosupressive drugs (transplant, suppress inflaamtion/autoimmine)
• chronic infection
  
  • HIV/AIDs most common
• Malignancy
  
  • Leukaemia, Lymphoma and Myeloma