Fungal infections Flashcards

1
Q

what are Mycoses?

what are primary fungal infections

what are oppoutunisitc fungal infections

A

mycoses= fungal ifnection, small number of the 100 pathogenic are clincially significant in healthy

Primary fungal infection- immunocompotent

oppourtunisitc fungal infections- immunocompromised

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2
Q

what are some common cutaneous fungal infections

A

athletes foot (tinea pedis)

general fungal infections of the skin (tinea corporis)

groin (tinea cruris)

nail infection (onychomycosis)

tinea verisoclor- interfere swith skin pigmentation

tinea cpaitis - fungal infection of the scalpe

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3
Q

Descibr tinea pedis

cuastive agent?

A
  • superificla skin infection caused by Tichiohyton rubrum (805)
  • working in hot, humid climates or working in high temperature enviornemtns and occulusive footwear most at risk
  • contratce nornally walking on syrface contaminated with infectious skin scales
  • 70% infected at some point in life
  • symptoms
    • scaly itchy or painful skin on the feet
      • between the toes (interdigigtal) or more widespread (moccasin)
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4
Q

what is this?

A

interdigital athletes foot

sclay ithcy painful skin on the feet

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5
Q

what is this?

A

moccasin widepsread athletes foot

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6
Q

what is the treatment for athletes foot

self care- good heygien, approptie fotowear

topical antifungal cream if mild not extensive ( terbinafine cream- or clotrimazole cream)

consider prescribing mildly potent topical corticosteriod if inflammed

oral Terbinafine if extensive

A
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7
Q

what is the causative agent of Tinea corporis

A

Trichopytom rubrum

or

trichophyton interdigital

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8
Q

tinea crusis is usally caused by…..

A

trichophyton rubrum, trichophyton interdigital

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9
Q

how are tinea corporis and tinea curis s(fungal infections of skin and gorin)m spread?

A

exposure to deswuamted skin flakes from infecte individuals (also zoonotic)

tinea cruiss is oftenc aused by scratching groin with finer nail containing infective material

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10
Q

risk factors of Tinea corprosi and tinea crusis

A

hot humid climates

working in high temrpature envuronemnt]guth fititng clothing

obesity

immuunocompromised states

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11
Q

symtpoms fo both tinea coprroris

A

hisotyr of itchy skin in the affected areas

single or mutlipemred or flat slightly raised ciruclar ring shape dpatches

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12
Q

what is this?

A

Tinea crusis

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13
Q

Treatment for Tiena crusis or Tinea corporis

A

topical fungal cream for non extnesive disease- terbinafine cream

consider prescri ign a mild potent topical corticosteriod if inflamamtion

consider prescribing oral terbinafine if extensive

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14
Q

what are symtoms of onychomycosis ( fungal nail)

A

the nauil looks abnormal, thickedn is dicosloured and briteel, generlaly invovles a singl nairl but others can be invovled?

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15
Q

What are the treamtnet options for Fungal nail (onychomycosis)

A

self care

keep short and filed down

antifungal only if uncomfrotable (cormobdiites, pyschological stress)

topcial anti-fungal if advised (generally amorofline 5%)

oral anti fungal if topical antifungals are unscusseful

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16
Q

what is Sporotirchosis

A

rare, subcutaneosu fungal infection

associated with handing decaying plant waste (rose handlers disease)

caustive agent (sporothrix schenckii)

  • symptoms
  • inital raised bump to from- progress and beocme larger to open sore or ulcertaed lesion that does not heal
  • satelite lesion may alos form
  • rarley pulmoanry disseminated disease
17
Q

What is the treatment for Sporotrichosis

A

oral antifungal for 6 months- Itraconazole

18
Q

what is mycetoma?

symptoms, cause, treatment?

A

subcutenaous skin infection fungal (cna be bacterial)

found in soil and water- most fungal ifnecitons caused by madurella grisea and Actinomadura madurae

  • symptoms
    • intially painless lesion—> abscess on foot—-> largher sore that leaks pus, blood erum, overtime destory undelying bone and muscle
  • treamtnet- as it is debillitating- surgical removal
19
Q

what is this?

A
  • Chromomycosis
    • caused mainly by Fronsecae Pedroso
    • most commonly found in tropical areas
    • begins as small painless lymp that professes ovterime to form srusty/sclart abscess
  • treatment
    • surgical removal/ long term anti fungal
20
Q

what are systemic fungal infections which may infected immunocompetent hosts?

A

Coccidiodymocosis (flu like sympotms- 10% long term lung,1% disseminate to skin/CNS/bone- symptoms nromamly resolve- endecmi to south america)

Histoplasmosis-(prevakent in south america, SE africa)-, associated with soils with high levesl of bat and bird droppings- immocompeten contained in lungs mild self limiting similar to Coccidiodes)- cna cause sevre dissemeninated in immunocmpromised

blastomycosis- common USA and canada

21
Q

what groups are susceptible to oppourtunisitc fungal infections

A

Those undergoing cancer treatment

Solid organ transplant recipients

Those receiving stem cell therapy

Neonates (pre-term)

Those with immunodeficiencies or who are immunocompromised

Intensive care patients

Complex surgical cases

In patients living with HIV

22
Q

Tinea pedis topic and oral treamtnets

A
  • topic
    • Terbinafine 1% cream for 7 days
    • clotrimaoole !% for 4 weeks
    • Miconazole 2% cream 2-6 weeks
  • oral
    • terbinafine
    • itraconzaole
23
Q

tu=inea crusis and tine coprois treatments oral and topica

A

Topical treatments

Terbinafine 1% cream for 7-14 dyas days

Clotrimazole 1% cream for 4 weeks

Miconazole 2% cream 10 days

Oral treatments

Terbinafine

Itraconazole

24
Q

Fungal nail infections treatment topical and oral?

A

Topical amorolfine paint

Oral treatments

Terbinafine

25
Q

Candiaiass Treatment for vaginal

A

Intravaginal cream: Clotrimazole 10%

Intravaginal pessaries: Clotrimazole 100mg Pessaries

Oral tablets- Fluconazole

26
Q

Oral candidiass treatment

A

Miconazole oral gel

Nystatin suspension

27
Q

mode of action fo Terbinafine

A

inhbti sfungal production of ergosterol—> fiugnal cell membranes

28
Q

mode of action of Azole antigunfals?

Clotriazomole

micaonzole

ketoconazole

ETC

Flucanzole

A

inhbits cytohrome P450 depeendent enzymes invovled in the biosyntheiss of cell merbane sterols

29
Q

How does nystain suppression for oral candiiasi work

A

bidns to ergosterol in fungal membrane formin pores- measn osmotic competence is lost

30
Q

how does amorolfine (nail paint) worK

A

inhbits production of ergosterol!