Immuno Practice

Question 1

Which of the following is required for sensitization of mast cells?

A. Stimulation of IgA class switching in B cells
B. One exposure to allergen
C. Binding of Ab to high affinity Fc receptors on the mast cell
D. Release of histamine and proteases
E. Antigen activation of Th1 cells

Answer 1

C. Binding of Ab to high affinity Fc receptors on the mast cell

Question 2

Which of the following is a property of mast cells but not basophils?

A. Present next to small blood vessels in normal tissues
B. Express high levels of surface FceRI receptorrs
C. Have cytoplasmic granules containing histamine
D. Cannot proliferate as mature cells
E. Are recruited into tissues from circulation

Answer 2

A. Present next to small blood vessels in normal tissues

Question 3

Which of the following proinflammatory mediators are preformed and stored in mast cell granules?

A. Prostaglandin D2
B. Leukotriene D4
C. Histamine
D. IL-4
E. Chemokines

Answer 3

C. Histamine

Question 4

Which of the following favors the development of immediate hypersensitivity?

A. Th1 responses to Ags
B. Infrequent Ag exposure
C. Strong innate immune responses to antigens
D. Production of IL-4 in response to Ags
E. Nonprotein Ags

Answer 4

D. Production of IL-4 in response to Ags

Question 5

Immediate hypersensitivity differs from delayed-type hypersensitivity in which one of the following ways?

A. Immediate hypersensitivity is a CD4 T cell mediated disease
B. Immediate hypersensitivity does not require previous exposure to Ag
C. Immediate hypersensitivity does not involve inflammation
D. Immediate hypersensitivity is driven by cytokines such as IL-4, IL-15, and IL-13
E. Immediate hypersensitivity typically leads to granuloma formation

Answer 5

D. Immediate hypersensitivity is driven by cytokines such as IL-4, IL-15, and IL-13

Question 6

Sensitization to foods is minimized by secretory IgA antibodies by:

A. The inflammatory response that occurs in the presence of food, these Abs and complement
B. Destroying the Ag presenting cells that would normally present the food Ags to T cells in the gut
C. Blocking the penetration of intact food products into the gut
D. All of the above

Answer 6

C. Blocking the penetration of intact food products into the gut