Immuno memorize - E3

Question 1

CD28

Answer 1

On T cell.
Binds B7 on APC.
Costimulator.

Question 2

CTLA-4

Answer 2

On T cell.
Competes with CD28 for binding to B7.
Turns off T cell.

Question 3

CD40L

Answer 3

On T cell.
Binds with CD40 on APC.
Costimulator pair.
Necessary for CSR on B cells.

Question 4

PD-1

Answer 4

On T cell.
Binds with PD-L1, PD-L2 on APC.
Turns off T cell.
Expressed on exhausted cells.

Question 5

B7

Answer 5

On APC/B cell.
Binds with CD28 on T cell.
Costimulator pair.

Question 6

CD40

Answer 6

On APC.
Binds with CD40L on T cell.
Costimulator pair.
Necessary for CSR on B cells.

Question 7

IL-2

Answer 7

T cell growth factor (during T cell activation)

Produced by CD4+ T cell

Question 8

IL-12

Answer 8

Produced by CD4+ T cell.
Stimulates Th1 (CMI)

Question 9

Th1

Answer 9

Stimulated by IL-12.

Produces IFNγ, IL-2 (CMI, B cells to make IgG3)

Question 10

IL-4

Answer 10

Produced by CD4+.
Stimulates Th2 (worms, allergens).

Question 11

Th2

Answer 11

Produced by CD4+.
Stimulated by IL-4.
Produces IL-4, IL-5, IL-13 (activates eosinophils, IgE, IgG4 for allergens/worms).

Question 12

IFNγ, IL-2

Answer 12

Produced by Th1.
Activate macrophages, NK, CD8+ T cells.
Cause B cells to produce IgG3.

Activates CMI for intracellular infections.

Question 13

IL-4, IL-5, IL-13

Answer 13

Produced by Th2.
Activate eosinophils.
Cause B cells to make IgE, IgG4.

Combats worms, allergens.

Question 14

Th17

Answer 14

Produced by CD4+.

Secretes IL-17, IL-22 (activates neutrophils, epithelia –> proinflammatory for extracellular pathogens).

Question 15

Treg

Answer 15

Produced by CD4+.

Secretes IL-10, TGF-beta (downregulates T cell response)

Question 16

IL-10

Answer 16

Produced by Treg.

Downregulates T cell response.

Question 17

IL-1, TNF

Answer 17

Produced by APC.

Increased adhesiveness.
CRP release.
Fever, depression, anorexia.

Question 18

chemokines

Answer 18

Produced by APC.

Attract other cells.

Question 19

IFNα, IFNβ

Answer 19

Produced by APC.

Antiviral cytokines. Neutralize viruses.

Question 20

IL-12

Answer 20

Produced by APC.

Activate Th1, NK cells.

Question 21

IL-10

Answer 21

Produced by APC.

Inhibitory: turns off immune response.

Question 22

IgM

Answer 22

Agglutination.
Complement activation.

Pentameric.
In blood.

Question 23

IgG

Answer 23

Neutralization.
Complement activation.
Opsonization.
ADCC.

Tissues and blood.
Passed to baby on birth.

Question 24

IgA

Answer 24

Neutralization.

Secretion on mucosal surfaces (mucus, milk, tears).
Dimeric.

Question 25

IgE

Answer 25

Mast cell activation.

Question 26

HLA B27

Answer 26

Ankylosing Spondylitis.

Question 27

HLA DR2, DQ1

Answer 27

narcolepsy

Question 28

HLA DR3, DR4

Answer 28

insulin dependent diabetes mellitus

Question 29

HLA DR4

Answer 29

Rheumatoid arthritis.

also insulin dependent diabetes mellitus

Question 30

FcγR

Answer 30

On NK cells:
Recognize IgG bound to viral antigens on infected cells or tumor antigens.
Triggers ADCC.

On mast cells:
Recognize IgE bound to parasitic antigens. (FcγR complexes with IgE BEFORE IgE binds to its antigen.
Causes a release of histamine, inflammation.)

On macrophages/neutrophils:
Recognize IgG coating bacteria.
Promotes phagocytosis.