Immuno memorize - E3 Flashcards
CD28
On T cell.
Binds B7 on APC.
Costimulator.
CTLA-4
On T cell.
Competes with CD28 for binding to B7.
Turns off T cell.
CD40L
On T cell.
Binds with CD40 on APC.
Costimulator pair.
Necessary for CSR on B cells.
PD-1
On T cell.
Binds with PD-L1, PD-L2 on APC.
Turns off T cell.
Expressed on exhausted cells.
B7
On APC/B cell.
Binds with CD28 on T cell.
Costimulator pair.
CD40
On APC.
Binds with CD40L on T cell.
Costimulator pair.
Necessary for CSR on B cells.
IL-2
T cell growth factor (during T cell activation)
Produced by CD4+ T cell
IL-12
Produced by CD4+ T cell. Stimulates Th1 (CMI)
Th1
Stimulated by IL-12.
Produces IFNγ, IL-2 (CMI, B cells to make IgG3)
IL-4
Produced by CD4+. Stimulates Th2 (worms, allergens).
Th2
Produced by CD4+.
Stimulated by IL-4.
Produces IL-4, IL-5, IL-13 (activates eosinophils, IgE, IgG4 for allergens/worms).
IFNγ, IL-2
Produced by Th1.
Activate macrophages, NK, CD8+ T cells.
Cause B cells to produce IgG3.
Activates CMI for intracellular infections.
IL-4, IL-5, IL-13
Produced by Th2.
Activate eosinophils.
Cause B cells to make IgE, IgG4.
Combats worms, allergens.
Th17
Produced by CD4+.
Secretes IL-17, IL-22 (activates neutrophils, epithelia –> proinflammatory for extracellular pathogens).
Treg
Produced by CD4+.
Secretes IL-10, TGF-beta (downregulates T cell response)
