Immuno memorize - E3 Flashcards
CD28
On T cell.
Binds B7 on APC.
Costimulator.
CTLA-4
On T cell.
Competes with CD28 for binding to B7.
Turns off T cell.
CD40L
On T cell.
Binds with CD40 on APC.
Costimulator pair.
Necessary for CSR on B cells.
PD-1
On T cell.
Binds with PD-L1, PD-L2 on APC.
Turns off T cell.
Expressed on exhausted cells.
B7
On APC/B cell.
Binds with CD28 on T cell.
Costimulator pair.
CD40
On APC.
Binds with CD40L on T cell.
Costimulator pair.
Necessary for CSR on B cells.
IL-2
T cell growth factor (during T cell activation)
Produced by CD4+ T cell
IL-12
Produced by CD4+ T cell. Stimulates Th1 (CMI)
Th1
Stimulated by IL-12.
Produces IFNγ, IL-2 (CMI, B cells to make IgG3)
IL-4
Produced by CD4+. Stimulates Th2 (worms, allergens).
Th2
Produced by CD4+.
Stimulated by IL-4.
Produces IL-4, IL-5, IL-13 (activates eosinophils, IgE, IgG4 for allergens/worms).
IFNγ, IL-2
Produced by Th1.
Activate macrophages, NK, CD8+ T cells.
Cause B cells to produce IgG3.
Activates CMI for intracellular infections.
IL-4, IL-5, IL-13
Produced by Th2.
Activate eosinophils.
Cause B cells to make IgE, IgG4.
Combats worms, allergens.
Th17
Produced by CD4+.
Secretes IL-17, IL-22 (activates neutrophils, epithelia –> proinflammatory for extracellular pathogens).
Treg
Produced by CD4+.
Secretes IL-10, TGF-beta (downregulates T cell response)
IL-10
Produced by Treg.
Downregulates T cell response.
IL-1, TNF
Produced by APC.
Increased adhesiveness.
CRP release.
Fever, depression, anorexia.
chemokines
Produced by APC.
Attract other cells.
IFNα, IFNβ
Produced by APC.
Antiviral cytokines. Neutralize viruses.
IL-12
Produced by APC.
Activate Th1, NK cells.
IL-10
Produced by APC.
Inhibitory: turns off immune response.
IgM
Agglutination.
Complement activation.
Pentameric.
In blood.
IgG
Neutralization.
Complement activation.
Opsonization.
ADCC.
Tissues and blood.
Passed to baby on birth.
IgA
Neutralization.
Secretion on mucosal surfaces (mucus, milk, tears).
Dimeric.
