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Path > Immuno EMQ notes > Flashcards

Immuno EMQ notes Flashcards

1
Q

Diminished T-cell count, non-funtional B-cells, IL-2 receptor mutation

A

SCID

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2
Q

Congenital neutropenia

A

Kostmann’s

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3
Q

Diminished B-cells, IgA/M/G, tyrosine kinase defect, BTK

A

Bruton’s

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4
Q

Crohn’s leading to loss of proteins and recurrent infx

A

Protein losing enteropathy

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5
Q

Mutation in CD40 ligand, Inc IgM, def IgA/E/G

A

Hyper IgM

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6
Q

High neutrophil count, Nitro Blue Tetrazolium (NBT) +ve

A

Leukocyte adhesion deficiency

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7
Q

Cyclical infx, elastase gene (ELA2)

A

Cyclical neutropenia

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8
Q

Nose bleeds, easy bruising, GI bleeds, reduced IgM, increased IgA+IgE

A

Wiskott-Aldrich syndrome

WASp gene mutation

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9
Q

MHC III mutation, low IgG, IgE, IgA

A

Common variable immunodeficiency Complement

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10
Q

Nitro-blue-tetrazolium test -ve, pneumonia, abscesses, X linked, NADPH oxidase defect

A

Chronic granulomatous disease

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11
Q

MHC I/II deficiency, sclerosing cholangitis, hepatomegaly, jaundice

A

Bare lymphocyte syndrome

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12
Q

recurrent chest and diarrhoeal illnesses

A

Selective IgA def

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13
Q

Granulocyte and lymphocyte deficiency

A

Reticular dysgenesis

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14
Q

Mouse monoclonal Ab targeted at CD3, used in allograft transplatation

A

OKT3/muromonab-CD3

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15
Q

Inhibits calcineurin, gum hyperplasia

A

Cyclosporine A

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16
Q

Anti-metabolite drug used in immunosupressive therapy, purine analogue

A

Azathioprine

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17
Q

Binds to FKBP-1a

A

Sirolimus

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18
Q

Binds to FKBP-1a targeting T-cell activation

A

Tacrolimus

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19
Q

Anti-CCP

A

RA

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20
Q

Anti-smooth muscle

A

Autoimmune hepatitis

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21
Q

Anti-jo, rash around eyes, pulmonary effects

A

Dermatomyositis

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22
Q

Reynaud’s, difficulty swallowing, anti-centromere

A

Limited systemic scleroderma/CREST

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23
Q

Widespread rash, pulmonary, anti-topoisomerase

A

Diffuse systemic scleroderma

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24
Q

p-ANCA, medium and small vessel vasculitis

A

Churg-Strauss

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25
Q

Dry mouth, dry eyes, exocrine destruction, parotid swelling, arthralgia, raised ESR

A

Sjogren’s

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26
Q

Saddle-shape nose, haemoptysis,haematuria, epistaxis, c-ANCA

A

Wegener’s

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27
Q

Type IV collagen, haemoptysis, haematuria

A

Goodpasture’s

28
Q

Myelin basic protein, weakness in legs, blurred vision

A

Multiple sclerosis

29
Q

Alkylating agent, used in SLE after steroids

A

Cyclophosphamide

30
Q

CTLA4-immunoglobulin fusion protein, used in resistant RA

A

Abatacept

31
Q

TNF-alpha antagonist,

A

Infliximab

32
Q

Osteoporosis Tx, RANK ligand

A

Denosumab

33
Q

Haematuria, after GI/resp infx, raised IgA

A

IgA nephropathy

34
Q

Anti-sterptolysin O titre, sore throat 2 weeks prior

A

Post streptococcal glomerulonephritis

35
Q

IgG/C3 immunofluorescence, end stage renal failure over a few days

A

Rapidly progressive glomerulonephritis

36
Q

Most common causes of nephrotic syndrome in children, lack of structural change on light microscopy,

A

Minimal change disease

37
Q

Deposition of IgA/IgM/IgG and C3 in GBM

A

Lupus nephritis

38
Q

Test to diagnose sarcoidosis

A

Kveim test

39
Q

Mutation of DeltaF508 on chromosome 7 effects which physical barrier

A

Mucociliary clearance

40
Q

Clasical pathway def (C1q/r/s, C2 + C4)

Abnormal test and associated conditions

A

CH50

SLE+RA

41
Q

Alternative pathway def (Factors B/I/P)

Abnormal test and associated conditions

A

AH50

Encapsulated bacteria

42
Q

Cells involved in anaphylaxis+allergy

A

Mast cells release of IgE

43
Q

Ab that protects resp, GI, lacrimal secretions

A

IgA

44
Q

HLA DQ2

A

Coeliac’s

45
Q

HLA B27

A

Ankylosing spondylitis

46
Q

HLA DR2, type II hypersens

A

Goodpastures

47
Q

HLA DR3

A

Grave’s, SLE, myasthenia gravis

48
Q

HLA DR4

A

T1DM, RA

49
Q

Alopecia, vitiligo, hypothyroidism, gonadal failure, T cell tolerance, AIRE

A

APECED

50
Q

Autoimmune mechanism in rheumatic fever

A

Molecular mimicry

51
Q

ABO incompatibility first immune response

A

C1

52
Q

Demoglien , Nikolsky’s sign

A

Pemphigus

53
Q

Immediate reaction provoked by re-exposure to an allergen.

IgE mediated degranulation of mast cells = releasing inflammatory mediators

A

Type I hypersensitivity

54
Q

Anaphylaxis, oral allergy syndrome, latex food syndrome, allergic rhinitis, acute urticaria, food allergy

A

Type I hypersensitivity

55
Q

IgG or IgM Abs targeting self antigen fixed to cell surface.

A

Type II hypersensitivity

56
Q

Haemolytic disease of the new born, AIHA, AITP, Goodpasture’s, Pemphigus vulgaris, Graves, Myasthenia gravis,

A

Type II Hypersensitivity

57
Q

Acute rheumatic fever, Pernicious anaemia, Churcg-Strauss, Wegener’s, Microscopic polyangiitis Chronic urticaria

A

Type II hypersensitivity

58
Q

IgG or IgM immune targeting self antigen not fixed to cell surface forming immune complexes

A

Type III Hypersensitivity

59
Q

SLE, Polyarthritis nodusa, serum sickness (penicilllin reaction),

A

Type III hypersensitivity

60
Q

Delayed hypersensitivity mediated by T cells

A

Type IV hypersensitivity

61
Q

DM, MS, RA, Crohn’s, contact dermatitis

A

Type IV hypersensitivity

62
Q

Monoclonal Ab directed against IL-2 receptor

Kidney transplant

A

Basiliximab

63
Q

Myaesthenic crisis

A

Plasmapheresis

64
Q

CD20 monoclonal Ab

A

Rituximab

65
Q

Fully human TNF-alpha monoclonal Ab

A

Adalimumab

66
Q

Anti-glycoprotein IIb/IIIa on plts

A

Autoimmune thrombocytopenic purpura

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