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Blackboard Q's path Flashcards

1
Q

Prevents DNA replication especially of T cells

A

Mycophenolate mofetil

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2
Q

Causes a transient increase in neutrophil count

A

Prednisolone

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3
Q

Immunisation still effective in this immunodeficiency syndrome

A

IgA def

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4
Q

Lymphocyte associated w/ HLA DR

A

CD4+

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5
Q

Lymphocyte associated w/ HLA A

A

CD8+

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6
Q

Most important cell in initiation of normal haemostasis

A

Endothelial

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7
Q

Main componenet involved in stabilising the primary haemostatis plug

A

Fibrin

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8
Q

Serine protease which assists in the break down of blood clots by binding to the clot and localising agents which break it down

A

Tissue-plasminogen activator (t-PA)

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9
Q

Potent plasmin inhibitor in the blood

A

a2 macroglobulin

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10
Q

MOA Heparin

A

Potentiates antithrombin

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11
Q

Measuring heparin activity

A

APTT

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12
Q

Measuring Warfarin activity

A

PT

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13
Q

Cyclic endoperoxides that induces plt aggregation

A

Thromboxane A2

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14
Q

Vit K dependent not serine protease

A

Protein S

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15
Q

Cofactor for protein C activity

A

Protein S

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16
Q

What synthesises tissue factpr, vWF, Prostacyclin, plasminogen activator, antithrombin III and Thrombomodulin

A

Vascular endothelium

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17
Q

Clotting factor that activates both FV and FVIII

A

Thrombin (FIIa)

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18
Q

Normal PT, inc APTT, normal plt count, dec FVIII and dec vWF

5yo

A

vWD

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19
Q

IV drug MOA: potentiates Antithrombin

A

Unfractionated heparin (UFH)

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20
Q

SubCut drug MOA: potentiates Antithrombin

A

Dalteparin (LWMH)

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21
Q

Reflects the amount of activity of fibrinogen

A

Thrombin Time

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22
Q

> 20% blast cells in BM

A

AML

23
Q

Dehdration and burning in fingers after hot bath (i.e. artificially raised Hb)

A

Pseudopolycythaemia

24
Q

CLL w/ new endobronchial mass/lymphoma

A

Richter’s syndrome

25
Q

Chemo pt, HTN, HyperK,

A

Tumour-lysis syndrome

26
Q

Commonest adult leukaemia

A

CLL

27
Q

3 phases of CML

A

Chronic (<5% blasts) Tx: Imatinib
Accelerted (>10% blasts)
Blast (>20% blasts)

28
Q

Neutrophil infiltrat, stomach erosions

A

Acute gastritis

29
Q

Gastroenteritis Staph A WCC effect

A

normal, too acute

30
Q

Final metabolite of Acyclovir

A

Acyclovir triphosphate

Herpes S

31
Q

Owl eye inclusion

A

CMV

Gancyclovir

32
Q

Hairy leukoplakia

A

EBV, acyclovir

33
Q

Vaccine thats contraindicated when hypersens to eggs

A

Influenza

34
Q

2nd line when allergic to penicillin

A

Erythromycin

35
Q

Canned food

A

Clostridium botulinum

36
Q

Sub-unit/conjugate vaccine

A

Pneumococcal vaccine

37
Q

Live attenuated

A

BCG, MMR, Yellow fever, Typhoid, Polio

38
Q

Detoxified exotoxin vaccine

A

Tetanus

39
Q

Recombinant DNA vaccine

A

HepB

40
Q

Which organism does the BCG contain

A

Mycobacterium bovis

41
Q

Conjugate vaccine

A

HiB

42
Q

ETOH and B?

A

B1 Thiamine

43
Q

Pellagra

A

B3. Dementia, Diarrhoea, dermatitis

44
Q

Megaloblastic anaemia

A

Folate def

45
Q

Pernicious anaemia

A

B12 def

46
Q

Askanazy cell

A

Hashimotos

47
Q

Prostate Ca

A

Acid phosphatase

48
Q

Rapid cardiac enzyme rise after MI

A

Creatine kinase MB

49
Q

Increased osteoblastic activity

A

ALP

50
Q

6 hrs, 12 hrs and inc for 3+ days cardiac marker

A

Troponin

51
Q

Def of which enzyme can cause SCID

A

Adenosine deaminase

52
Q

Fabry’s

A

Galactosidase A

53
Q

3 drugs contraindicated in porphyria

A

Diclofenac, ETOH, co-trimoxazole

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