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M3 Pharm B1 > Immuno Drugs > Flashcards

Immuno Drugs Flashcards

1
Q

Acquired Immunity: 2 subtypes

A

Natural and Artificial

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2
Q

Acquired Immunity - Natural: 2 subtypes and their meanings

A
  1. Actively acquired: Having the disease

2. Passively acquired: Antibodies through placenta or breast milk

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3
Q

Acquired Immunity - Artificial: 2 subtypes and their meanings

A
  1. Actively acquired: Antibodies produced through immunization vaccine or toxoid
  2. Passively acquired: Injection of antibodies (immunoglobulins)
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4
Q

Hepatitis B immuneglobulin: immunity type

A

Artificial passive immunity

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5
Q

MMR: Buzzword

A

Buzz word: Artificial active immunity

Indicated at 12 mos.
Contraindicated in pregnancy (because it’s a live vaccine)

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6
Q

Immunosuppressants and Immunomodulators

A

Immunosuppressant drugs such as corticosteroids suppress T-cells

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7
Q

Lab tests done before giving immunosuppressant drugs (4)

A
  1. BUN and Cr
  2. CBC
  3. Platelets
  4. Hepatic enzymes
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8
Q

Agents used during organ transplants: Cyclosporine

A

MOA: Binds to cyclophillin and leads to decrease of calcineurin —> inhibition of IL-3, IL-3, IFN-gamma

Usually combined with corticosteroids

Adverse effects: Nephrotoxicity and Gingival hyperplasia

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9
Q

Agents used during organ transplants: Azathioprine

A

MOA: Converted to 6-mercaptopurine –> immunosuppression

Adverse: Leukopenia, thrombocytopenia, hepatotoxicity

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10
Q

Agents used during organ transplants: *Muromonab-CD3

A

Monoclonal ab to CD-3 glycoprotein

Buzzword: Acute renal transplant rejection

*Must administer methylprednisone before IV muromonab-CD3 to precent cytokine release syndrome

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11
Q

Agents used during organ transplants: Sirolimus (rapamycin)

A

Macrolide Antibiotic
Mamalian Target of rapamycin (mTOR inhibitor)

MOA: Forms a complex with FK12-binding protein and inhibits T-cell proliferation

Adverse: Myelosuppression

Metabolized by CYP450

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12
Q

Agents used during organ transplants: Tacrolimus

A

Macrolide Antibiotics
Tacrolimus & Cyclosporine bind to immunophilins (Cyclophilin and FK506-binding protein)

MOA: Calcineurin inhibitors of IL-2

Indicated in renal and liver transplants

Ointment rx of atopic dermatitis and psorioasis

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13
Q

Agents used during organ transplants: Mycophenlate

A

MOA: Inhibits de novo syntheisis of purines

Used in combo with cyclosporine

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14
Q

Agents used during organ transplants: Thalidomide

A

Inhibits angiogenesis
Teratogenic cause phocomelia and congenital malformation

Drug prevents vascular growth during fetal limb development
Immunosuppressant and immunostimulant

Inhibits IL-2, TNF and other cytokines

Clinical use: Cancer, TB, leprosy, erythema, nodosum leprosum, AIDS-associated wasting syndrome (Cachexia)

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15
Q

Agents that serve to STIMULATE immune response: Buzzword, Indications, and Adverse

A

Buzzword: IV and IM immunoglobulins

Indications: Rx of congenital agammaglobulinemia, AI disease, and Guillan-Barre syndrome

Adverse: Hypersensitivity rxns

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16
Q

Rh Incompatibility: If mom ab screen is Rh-

A

Answer Rhogam at 28 weeks of pregnancy and 72 hours post partum if baby is Rh+

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17
Q

Rhogam

A

Human IgG to red cell Rho(D) antigen. Neutralizes Rh+, so mom will not make ab (making it safe for second pregnancy)

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18
Q

Rh Incompatibility: If mom ab screen is Rh+

A

Don’t give rhogam, do titer measure because mom has been exposed already and this will go to the baby and cause hemolysis

19
Q

Cytokines: IFN-alpha

A

Hepatitis, leukemia

20
Q

Cytokines: IFN-beta

A

Multiple sclerosis

21
Q

Cytokines: IGN-gamma

A

Chronic granulomatous disease

22
Q

Cytokines: IL-11

A

Thrombocytopenia

23
Q

Cytokines: Erythropoetin

A

Anemia

24
Q

Cytokines: Aldesleukin (IL-2)

A

Renal Cell Carcinoma

25
Q

Cytokines: Filgrastim (G-CSF)

A

Bone marrow recovery

26
Q

Cytokines: Sargramostim (GM-CSF)

A

Bone marrow recovery

27
Q

Monoclonal Antibodes (“Mab”): Abciximab

A

IIb/IIa receptor inhibitors

28
Q

Monoclonal Antibodes (“Mab”): Infliximab

A

Rheumatoid arthritis

29
Q

Monoclonal Antibodes (“Mab”): Omalizumab

A

Asthma

30
Q

Monoclonal Antibodes (“Mab”): Trastuzumab

A

Breast cancer

31
Q

Monoclonal Antibodes (“Mab”): Daclizumab (IL-2)

A

Renal transplants

32
Q

Monoclonal Antibodes (“Mab”): Muromonab

A

Renal transplants

33
Q

Monoclonal Antibodes (“Mab”): Palivizumab

A

Respiratory Syncytial Virus (RSV)

34
Q

Monoclonal Antibodes (“Mab”): Rituximab

A

Non-Hodgkin’s Lymphoma

35
Q

Newly Approved MABs: Adalimumab

A

Rheumatoid arthritis

36
Q

Newly Approved MABs: Bevacizumab

A

Metastatic cancer

37
Q

Newly Approved MABs: Rituximab

A

Lymphoma

38
Q

Newly Approved MABs: Visilizumab

A

Crohn’s Disease

39
Q

Newly Approved MABs: Basiliximab (IL-2)

A

Renal Transplants

40
Q

Advice Buzzwords: Risk for low acquired immunity

A

Staying home for 3 month old baby

41
Q

Advice Buzzwords: Will improve baby’s defense system

A

Breast feeding even for a short time

42
Q

Advice Buzzwords: First Ig produced during infection

A

IgM

43
Q

Advice Buzzwords: The only Ig that crosses the placenta and gives baby passive immunity

A

IgG

M3 Pharm B1 (8 decks)

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