Basic Pharm 5 Flashcards
1
Q
Maintenance Dose (MD) =
A
Cp x clearance x time / f
2
Q
Infusion rate (Ko)
A
Steady-state concentration x clearance
3
Q
Half-life (t 1/2)
A
0.7/ ke (Double check this)
4
Q
Half-life affected by Vd
A
0.7 x Vd/Cl
5
Q
Clearance
A
0.7 Vd / half-life
6
Q
1st order elimination
A
NOT LINEAR
Constant fraction (%) of drug eliminated per time
Half-life is constant
Majority of drugs follow half-life
7
Q
Zero order elimination
A
Constant AMOUNT of drug is eliminated per time
Independent of plasma concentration
Half-life is VARIABLE
E.g. Phenytoin, Ethanol, Aspirin (PEA)
