Basic Pharm 3

Question 1

Unionized or Non-ionized

Answer 1

LIPID SOLUBLE, cross membranes

Question 2

Ionized

Answer 2

WATER SOLUBLE, excreted

Question 3

Weak Acids: pH-pKa = log?

Answer 3

Ionized / Unionized or nonionized

Question 4

WBs: pH-pKa = log?

Answer 4

Unionized or non-ionized / ionized

Question 5

Acid medium with Acid is?

Answer 5

Unionized or non-ionized (lipid soluble, cross membranes)

Question 6

Acid medium with Base is?

Answer 6

Ionized (water soluble), excreted

Question 7

Base medium with Acid is?

Answer 7

Ionized (water soluble), excreted

Question 8

Base medium with Base is?

Answer 8

Unionized or non-ionized

Question 9

If you overdose on a weak acid (e.g. aspirin or phenobarbital), what happens to urine?

Answer 9

Alkalinization of urine (NaHco3-)

Question 10

If you overdose on a weak base (e.g. amphetamine), what happens to urine?

Answer 10

Acidification of urine (NH4Cl)

Question 11

If pH-pHa = 0, what is the media?

Answer 11

Neither acidic nor basic

So it’s 50% ionized, and 50% unionized or non-ionized

Question 12

What is CMax?

Answer 12

Maximum drug concentration

Question 13

What is TMax?

Answer 13

Time at which Cmax occurs

Question 14

What is MEC?

Answer 14

Minimum effective concentration

Question 15

Drug should stay between what two graphical factors in plasma drug concentrations?

Answer 15

Between Cmax and MEC

Question 16

If it is > Cmax, what happens?

Answer 16

Toxic effects

Question 17

If it is < MEC, what happens?

Answer 17

Ineffective, no response

Question 18

What is bioavailability (f)?

Answer 18

Fraction amount of drug available at site of action in unchanged form

Question 19

What’s the bioavailability (f) standard route?

Answer 19

IV, it’s 100%, so f = 1

Question 20

If you’re administering oral, sublingual, or other routes, you get bioavailability (f) by comparing it with what route?

Answer 20

IV route

Question 21

Bioavailability (f) equation

Answer 21

f = AUC (route administered other than IV) / AUC injected x 100

Question 22

What is the Area Under the Curve (AUC)?

Answer 22

Drug concentration in the plasma

Question 23

What is bioequivalence important for? (see notes)

Answer 23

Generic drugs

Need to prove that formulation = patent company’s formulation