Immuno drugs Flashcards
Target/use of alemtuzumab?
CD52, CLL
Target/use of bevacizumab?
VEGF, colorectal cancer/renal cell carcinoma
Target/use of cetuximab?
EGFR, stage IV colorectal cancer and head/neck cancer
Target/use of rituximab?
CD20, B cell non-Hodgkin lymphoma/rheumatoid arthritis/ITP
Target/use of trastuzumab?
HER2/neu, breast and gastric cancer
Target/use of infliximab, adalimumab?
TNF alpha, PAIR diseases
Target/use of natalizumab?
Alpha4-integrin, multiple sclerosis and Crohn disease
Target/use of abciximab?
GpIIbIIIa, prevention of ischemic complications in patients undergoing percutaneous coronary intervention
Target/use of denosumab?
RANKL, osteoporosis
Target/use of digoxin immune fab?
Digoxin, antidote for digoxin toxicity
Target/use of omalizumab?
IgE, allergic asthma (prevents IgE binding to the Fc receptor)
Target/use of palivizumab?
RSV F protein, RSV prophylaxis for high-risk infants
Natalizumab targets alpha4-integrin. What does alpha4-integrin do?
Leukocyte adhesion
Natalizumab increases the risk of what disease in a select patient group?
Increased risk of PML in patients with JC virus
Epoetin alfa is a recombinant cytokine of what and what is it used for?
Epo - anemias especially in renal failure
Oprelvekin is a recombinant cytokine of what and what is it used for?
IL-11, thrombocytopenia
Filgrastim is a recombinant cytokine of what and what is it used for?
G-CSF, recovery of bone marrow
Sargramostim is a recombinant cytokine of what and what is it used for?
GM-CSF, recovery of bone marrow
Aldesleukin is a recombinant cytokine of what and what is it used for?
IL-2, renal cell carcinoma and metastatic melanoma
What is thrombopoietin used for?
Thrombocytopenia
What is IFN-alpha used for?
Chronic hepatitis B and C, Kaposi sarcoma, hairy cell leukemia, condyloma acuminatum, renal cell carcinoma, malignant melanoma
What is IFN-beta used for?
Multiple sclerosis
What is IFN-gamma used for?
Chronic granulomatous disease
What two drugs inhibit calcineurin?
Cyclosporin and tacrolimus?
What does cyclosporin bind to?
Cyclophilin
What does tacrolimus bind to?
FK506 binding protein
What does sirolimus (rapamycin) do?
mTOR inhibitor
What IL do all the immunosuppressant drugs for prevention of transplant rejection ultimately work on?
Work to prevent IL-2 transcription and signal transduction
Target and use of basiliximab?
Blocks IL-2R, kidney transplant rejection prophylaxis
What is the mechanism by which glucocorticoids are used in transplant rejection prophylaxis?
Inhibit NF-kB - suppress both B and T cell function by decreased transcription of many cytokines
