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ALL THE PHARM > Immuno drugs > Flashcards

Immuno drugs Flashcards

1
Q

Target/use of alemtuzumab?

A

CD52, CLL

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2
Q

Target/use of bevacizumab?

A

VEGF, colorectal cancer/renal cell carcinoma

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3
Q

Target/use of cetuximab?

A

EGFR, stage IV colorectal cancer and head/neck cancer

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4
Q

Target/use of rituximab?

A

CD20, B cell non-Hodgkin lymphoma/rheumatoid arthritis/ITP

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5
Q

Target/use of trastuzumab?

A

HER2/neu, breast and gastric cancer

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6
Q

Target/use of infliximab, adalimumab?

A

TNF alpha, PAIR diseases

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7
Q

Target/use of natalizumab?

A

Alpha4-integrin, multiple sclerosis and Crohn disease

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8
Q

Target/use of abciximab?

A

GpIIbIIIa, prevention of ischemic complications in patients undergoing percutaneous coronary intervention

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9
Q

Target/use of denosumab?

A

RANKL, osteoporosis

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10
Q

Target/use of digoxin immune fab?

A

Digoxin, antidote for digoxin toxicity

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11
Q

Target/use of omalizumab?

A

IgE, allergic asthma (prevents IgE binding to the Fc receptor)

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12
Q

Target/use of palivizumab?

A

RSV F protein, RSV prophylaxis for high-risk infants

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13
Q

Natalizumab targets alpha4-integrin. What does alpha4-integrin do?

A

Leukocyte adhesion

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14
Q

Natalizumab increases the risk of what disease in a select patient group?

A

Increased risk of PML in patients with JC virus

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15
Q

Epoetin alfa is a recombinant cytokine of what and what is it used for?

A

Epo - anemias especially in renal failure

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16
Q

Oprelvekin is a recombinant cytokine of what and what is it used for?

A

IL-11, thrombocytopenia

17
Q

Filgrastim is a recombinant cytokine of what and what is it used for?

A

G-CSF, recovery of bone marrow

18
Q

Sargramostim is a recombinant cytokine of what and what is it used for?

A

GM-CSF, recovery of bone marrow

19
Q

Aldesleukin is a recombinant cytokine of what and what is it used for?

A

IL-2, renal cell carcinoma and metastatic melanoma

20
Q

What is thrombopoietin used for?

A

Thrombocytopenia

21
Q

What is IFN-alpha used for?

A

Chronic hepatitis B and C, Kaposi sarcoma, hairy cell leukemia, condyloma acuminatum, renal cell carcinoma, malignant melanoma

22
Q

What is IFN-beta used for?

A

Multiple sclerosis

23
Q

What is IFN-gamma used for?

A

Chronic granulomatous disease

24
Q

What two drugs inhibit calcineurin?

A

Cyclosporin and tacrolimus?

25
Q

What does cyclosporin bind to?

A

Cyclophilin

26
Q

What does tacrolimus bind to?

A

FK506 binding protein

27
Q

What does sirolimus (rapamycin) do?

A

mTOR inhibitor

28
Q

What IL do all the immunosuppressant drugs for prevention of transplant rejection ultimately work on?

A

Work to prevent IL-2 transcription and signal transduction

29
Q

Target and use of basiliximab?

A

Blocks IL-2R, kidney transplant rejection prophylaxis

30
Q

What is the mechanism by which glucocorticoids are used in transplant rejection prophylaxis?

A

Inhibit NF-kB - suppress both B and T cell function by decreased transcription of many cytokines

ALL THE PHARM (10 decks)

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