Immuno Flashcards
what cell in inhibited by the presence of MHC1 on cells
NK cells
org invades cell - damages MHC1 -> hidden from rest of immune response but attacked by NK cells
what cancer develops in Barrett’s oesophagus
Adenocarcinoma
Mechanism in esophagus as a result of GORD (reflux) that results in cancer
Metaplasia
what happens to the Body of the stomach in pernicious anaemia
atrophic gastritis (weakened stomach lining)
what cancer do you get with H pylori
MALT
what cancer do you get in coeliac if you dont follow a gluten free diet
lymphoma
Most common breast malig
inv ductal carcinoma
DCIS = most common non-invasive
Breast cancer - E cadherin +ve
inv ductal carcinoma
Breast C - E cadherin -ve
inv lobular carcinoma
Breast fibro-epithelial tumour with abundant stromal elements
phyllodes tumour
Low enzyme -> hyperuricaemia/rise in blood uric acid
HGPRT (lesch Nyhan syndro)
what enz regulates the rate limiting step in haem biosynthesis
ALA Synthase
What enz is raised in mumps
Amylase S
which biomarker raised in Rhabdomyolysis
Creatine Kinase
raised anti-mitochondrial antibody
Primary biliary cirrhosis/cholangitis
raised anti CCP
rheumatoid arth
raised anti acetylcholine receptor Ab
myasthenia gravis
anti SSB/La Ab
anti-SSA/Ro Ab
Sjogrens
raised tissue transglutamase ab
coeliac
raised anti endomysial an
coeliac
anti smooth-muscle Ab
AI hep
PSC
raised cANCA
small vessel vasc - esp Wegener’s Granulomatosis
raised pANCA
PSC
anti-glomerular basement memb ab
goodpastures
anti IF abs
pernicious anaemia
anti-microsomal Abs
chronic lymphocytic thyroiditis (hashimotos)
TSHR Abs
Graves
Anti Jo-1 Ab
polymyositis and dermatomyositis
anti Scl70
systemic sclerosis
ACAs (anti centromere Abs)
CREST syndro
woman presents with dry eyes and parotid swelling
Sjogrens syndro
what do you measure to measure progress of SLE
C3/C4
anti ds-DNA
Hx of multiple staph skin and soft tissue inf
Aspergillus inf
chronic granulomatous disease
Hx of neutrophilia, absent pus in ulcers + delayed umbilical cord cutting
Leukocyte adhesion def 1
Kid with recurrent inf, doesnt have any B cells
Brutons X linked gammaglobinaemia
Kid with inf, +ve nitro blue tetrazolium
myeloperoxidase def
kid with no CD4+, but CD8+ and B cells present
Bare lymphocyte syndro
recurring mycobac inf
get TB following BCG vaccine
IFN Gamma R def
Neck swelling - stained and gives a “starry sky” appearance
Burkitt’s Lymphoma
Chr mutation (9,22) -> what cancer
CML
Chr mutation (15,17) -> what cancer
AML
lrg cells with basophillic cytoplasm and nucelus clock-face chromatin without nuclei
+/- Rouleaux
MM
tense bulla on flexural surfaces of elderly, T2 hypersensitivity
bullous pemphigoid
wickham striae in buccal cavity
Lichen Planus
recurrent inf since birth, neutrophil count normal, nitro blue tetrazolium test - remains colourless
CGD
haematuria, red and white cell casts, hypertensive, passing urine less
nephritic syndro
haemoptysis, haematuria, renal F, biopsy shows crescent morphology
good pastures syndro
-> rapidly progressing glomeruloneph
recurrent chest inf and bouts of diarrhoea
selective IgA def
