Histo

Question 1

Sympto of UTI + acute onset costovertebral pain

pus cells + blood in urine

Answer 1

MM

Acute pyelonephritis

Question 2

lady with loin to groin pain, haematruria and pain at end of micturition

Answer 2

Renal calculi

Question 3

fat man with AF develops fever, nausea, vomiting and right loin pain

Answer 3

Renal infarct

Question 4

massive adbo mass in child,

maybo inc BP/haematuria

Answer 4

Wilm’s tumour

Question 5

Renal problems asso with heroin use

Answer 5

focal glomerulonephritis

Question 6

Man wants to start taking allopurinol for Gout. what other medication must be stopped

Answer 6

Azathioprine

6-mercaptopurine

Question 7

what cancer does asbestos cause

Answer 7

mesothelioma

Question 8

most specific marker for rheumatoid arth

Answer 8

anti-ccp

Question 9

most common malig ovarian tumour

Answer 9

serous carcinoma

Question 10

most common benign ovarian tumour

Answer 10

serous cystadenoma

Question 11

most common benign ovarian tumour in <25

Answer 11

mature teratoma

Question 12

failure to suppress at high dose dexamethasone supp test

Answer 12

ectopic ACTH

Question 13

+ve low dose dexamethasone suppression test but suppressed at high dose

Answer 13

cushings disease

Question 14

Most common cause of glomerulonephritis in kids

Answer 14

minimal change disease

Question 15

bone cancer in >40 at femur/pelvis

Answer 15

chondrosarcoma

Question 16

‘onion skin’ periosteal on X-ray

Answer 16

Ewing’s sarcoma

Question 17

Diarhoea and weight loss, patchy inflam on endoscope

granulomata

Answer 17

Crohn’s disease

Question 18

liver biopsy reveals portal hepatitis and granulomatous destruction of bile ducts

Answer 18

PBC

Question 19

Jaundice + UC - what would you also suspect

Answer 19

PSC

Question 20

what does denusomab target

Answer 20

RANKL - receptor activator of nuclear factor kappa-B ligand

Question 21

recurrent fever and mutation in MEFV geen

Answer 21

familial Mediterranean fever

ME-FV = Mediterranean Fever

Question 22

mixed pattern auto-inflam condition has >90% heritability and effects sacro-iliac joints

Answer 22

ank spond

Question 23

HLA-DR27 + affects sacro-illiac joints

Answer 23

ank spond

Question 24

what enz raised in obs jaundice

Answer 24

GGT - gamma glutamyl transpeptidase

Question 25

hyperthyroidism, low TSH and high thyroxine, not good uptake on technitium scan

Answer 25

Viral de Quervains thyroiditis

Question 26

hyperthyroidism - good uptake on technitium scan

Answer 26

Graves

Question 27

elderly man fall - doesnt become unconcious, presents 2 days later with confusion etc

Answer 27

subdural hemorrhage

Question 28

fall - loss of conciousness then lucid interval then LoC again

Answer 28

extradural haemorrhage

Question 29

biomarker raised in medullary thyroid cancer

Answer 29

calcitonin

Question 30

biomrarker for papillary and follicular thyroid carcinomas

Answer 30

thyroglobulin

Question 31

most common thyroid carcinom

Answer 31

papillary > Follicular > medullary

Question 32

what cancer if keritin and Intracellular bridges present

Answer 32

Sq cell carcinoma

Question 33

high Na, low K, low renin

likely cause?

Answer 33

pri hyperaldos (Conn’s)

Question 34

pain, mass at knee
X ray = mixed lytic and sclerotic lesions
bone formation in tumour
tumours cells +ve for ALP
codlins triangle raised

Answer 34

Osteosarcoma

Question 35

pain + difficulty bending knee,
X ray -> lytic lesions (soap bubble),
multinucleate cells

Answer 35

Giant cell tumour