Haem

Question 1

Blood trasnfusion

Several days later - Feverish + low Hb + Jaundice

Answer 1

Delayed Haemolytic Transfusion reaction

Question 2

Blood transfusion -

several hour later develops rash

Answer 2

Allergic reaction

Question 3

Transfusion - 6ish hours later
HypoT, Tachy, Fever, SOB
Bilat infiltrates/Oedema
Fever

Answer 3

TRALI

Question 4

Reg transfusions

presents with malaise + ED

Answer 4

T asso haemosiderosis

Question 5

10mins after transfusion

Tachycardic, transfusion site pain, HypoT

Answer 5

ABO/Rh incompatanbility

Question 6

Lady with multi kids having another child - req transfusion due to blood loss
During transfusion - neg reaction

Answer 6

acute febrile non-haemolytic reaction

med by recipient Abs forming vs WBC-HLA from compatible donor blood

Question 7

Coeliac that refuses to stick to gluten free diet -> macrocytic anaemia

Answer 7

folate def

Question 8

spherocytes, polychromasia and reticulocytosis on blood film

Answer 8

Heri Sphero

Question 9

haemolysis after antimalarias

Answer 9

G6PDD (antimalarials -> acute haemolysis)

Question 10

Back pain, Raised Ca

Raised IgG

Answer 10

MM

Question 11

IgM paraprotein
visual disturbances
weakness, purpura, arthralgias

Answer 11

Waldenstrom macroglobinaemia

= lymphoplasmocytic lymphoma

Question 12

german woman, recurrent UTIs, low neutrophils, no abnormal cells on film

Answer 12

Chronic idiopathic neutropenia

Question 13

Young man, pancytopenia + immature myeloid cells

normal WCC

Answer 13

AML

Question 14

most common cause of low platelets in preg

Answer 14

gestational thrombocytopenia

Question 15

Causes of DIC in preg

Answer 15

placental abruption (most common)
amniotic fluid embolus

Question 16

Thrombocytopenia + Anaemia + renal F

Answer 16

HUS

Question 17

Thrombocytopenia + Anaemia + renal F + Fever + mental state changes + normal PT/PTT

Answer 17

TTP

Question 18

Thrombocytopenia + Anaemia + renal F + Fever + mental state changes + abnormal PT/PTT

Answer 18

DIC

Question 19

periph blood shows WBCs with filamentous projections

Answer 19

Hairy cell lymphoma

Question 20

periph blood shows lymphocytes with finger-like projections of cytoplasm

Answer 20

Hairy cell lymphoma

Question 21

Smudge cells

/ couldnt read periph smear

Answer 21

CLL

Question 22

Owl eye cells

reed-sternburg cells

Answer 22

Hodgekins lymphoma

Question 23

Man has intermittent mouth and tongue swelling, unresponsive to anti-histamines, in on anti HTN medication

Answer 23

drug-induced angiooedema

ACEi or Aspirin

Question 24

what feature is characteristic of ALL

Answer 24

neutropenia

Question 25

low serum iron, high TIBC, low ferritin

Answer 25

Fe def anaemia

Question 26

massive splenomeg
tear-drop poikilocytes
JAK2 V617F mut

Answer 26

myelofibrosis

Question 27

aortic valve replacement -> few weeks later w/ jaundice, haemagloninuria, inc reticulocytes

Answer 27

mechanical haemolytic anaemia

Question 28

inc Hb, inc Plt, inc haematocrit

itchy when in baths, headaches, visual disturbances, tired

Answer 28

polycythaemia tuba vera

Question 29

Tx for ploycythemia rubs vera

Answer 29

hydroxycarbamide (dec bone func)

Question 30

+ve coombs tests - suggests?

Answer 30

ai haemolytic anaemia

Question 31

Tx for CLL with p53 mut

Answer 31

ibrutinib

Question 32

Lymphoma with (11,14) translocation, over expression of BCL2 and Cyclin D1

Answer 32

mantle cell lymphoma

Question 33

kid with anaemia and dactylitis

Answer 33

sickle cell