ChemPath Flashcards
Low Na, Normal Osmo
Pseudo-hyponatraemia
- hyperlipid/hyperprot
hyponat, Urine osmo >20
renal cause hyponat (CKD, diuretics)
hyperpigmentation, Hyponat, hyperkal
Addisons
hyponat with inappropriately high urine osmo
SIADH
hyponat with raised plasma osmo
ethanol, glucose, mannitol
hyperkalaemia + deranged urea/creatinine levels
Renal failure
Hypokalaemia, calcium in urine, hypotension
In babies
Bartter syndro
hypokalaemia with acidosis
renal tubular acidosis
rises in GGT and ALP that are greater than the rises in AST/ALT
cholestasis (from gallstones)
Normal LFTs, isolated rise in unconjugated bilirubinaemia, normal conjugated bilirubinaemia
Gilbert syndro
raised AST and ALT levels (AST:ALT ratio <1), Inc GGT
Normla BIlirubin/albumin
NAFLD
AST and ALT >1000, AST/ALT higher than GGT and ALP
hepatic pathilogy - paracetamol poisoning?
Hyponat, Hyperkal, +ve short synthacthen
Long synthACTHen - cortisol <900 after 24 hrs
primary adrenal insuff (addisons)
hyponat, hyperkal, +ve short synthacth,
Long synACTHen - cortison >900 after 24hrs
secondary adrenal insufficiency
Normal calcium bone studies, isolated rise in ALP
Paget’s
Inc PTH, low/inappropriately normal Ca, inc ALP
Osteomalacia
dec PTH, hypocal, hyperphos
pri hypoparathyroidism
bone disease with normal bone studies
Osteoporosis
raised amylase in child with parotitis
Mumps
causes of raised amyllase
inflam of parotid glands, pancreatitis
Bence-Jones plasma protein
MM
CA125
Ovarian cancer
low plasma ceruloplasmin levels
wilsons disease
raised alpha fetoprotein
hepatocellular carcinoma
germ cell tumours
raised plasma albumin
dehydration
low plasma albumin
liver disease, nephrotic syndro, malabs
corrected Ca calculation
Serum Ca + 0.02 x(40-serum albumin)
NB low albumi -> low bound Ca, normal Free Ca
Osteonec of jaw
bisphosphonate treatment (alendronate)
ECG - early peaked t waves, broad QRS, flat P waves
hyperkal
Inc ALT > inc ASP > inc GGT + ALP
hep (prob viral)
Inc ASP > inc ALT > inc GGT + ALP
alco hep
isolated rise in unconjugate bilirubin, Normal ALP/ALT etc
Gilbret’s syndro
ALP v raised on its own, other results normal
Hx of headaches
Pagets
blood tests show hypoketotic hypoglycaemia
MCADD
high phelyalanine levels in blood
retardation
PKU
AKI, inc anion gap, calcium oxalate crystals in urine
ethylene glycol poisoning
vitamine def
anaemia, poor coordination, absent reflexes
Vit E
vitamine def
being treated for TB, dev rash on skin
Vit B6
hyponat, urine Cosmo <20, ankle oedema
congestive cardiac F