immuno 1 Flashcards

1
Q

what percent of total body weight is blood

A

8

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2
Q

what are the components that make up blood and what are they suspended in

A

plasma

erythrocytes
leukocytes
thrombocytes

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3
Q

erythrocytes

A

red blood cells- whole cells
99%

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4
Q

leukocytes

A

white blood cells- whole cells

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5
Q

throbocytes

A

platelets- cell fragments

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6
Q

dispersion of cells in plasma

A

generally evenly dispersed in plasma

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7
Q

what do hematocrit levels represent

A

the percentage of rbc in total volume

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8
Q

average hematocrit levels in women and men

A

42% women
45% men
plasma makes up the remaining volume

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9
Q

what makes up 90% of plasma

A

water

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10
Q

what does plasma serve as

A

the medium to carry the components within the blood

has high capacity to hold heat and helps distribute heat throughout the body

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11
Q

what does plasma consist of other than water

A

several inorganic substances including electrolytes (ions) such as Na Cl K Ca H2CO3———–function as regulators of membrane excitability, osmotic distribution between extracellular fluid and cells and pH buffering

organic substances such as plasma proteins, glucose, AA, lipids, vitamins, creatine, bilirubin, hormones, and gases

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12
Q

what is serum

A

the part of blood which is similar in composition to plasma but lacks the clotting factors

it is the liquid part of blood after clotting is allwoed to occur

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13
Q

what do blood tests require

A

some require serium while others require plasma

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14
Q

where are plasma protiens synthesized

A

most in the liver
exception- gamma globulins aka antibodies

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15
Q

what do plasma proteins do

A

establish osmotic gradient bw blood and interstitial fluid (colloid osmotic pressure) and prevents excessive losss of plasma from capillaries intot he interstitial fluid and maintains plasma volume

helps in maintaining the plasmas capacity to buffer changes in pH

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16
Q

what are the 3 groups of plasma protiens

A

albumins
globulins
fibinogen

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17
Q

what plasma protines are the most abundant

A

albumins

18
Q

what plasma proteins contibutes to colloid osmotic pressure

A

albumins

19
Q

what plasma proteins nonspecifically bind to many substnaces that are poorly soluble in plasma to aid in their transport

A

albumins

20
Q

what are the 3 types of globulins

A

alpha
beta
gamma

21
Q

what plasma proteins specifically bind to poorly soluble substances to carry them

A

globulins

22
Q

what plasma protiens include substances involved in blood clotting cascade

A

globulins

23
Q

what are the other functions of globlulins

A

activation of other protiens and important in host defense

24
Q

what is the function of fibrinogen

A

key factor in clotting cascade

25
Q

where does filtration occur and what happens

A

in the arterial end
10mmHg pressure
fluid exits capillary due to 35mmHg capillary hydrostatic pressure beinggreater than the blood colloidal osmotic pressure whichi s 25mmHg

26
Q

what happens mid cappilary

A

no net movement of fluid since capillary hydrostatic pressure and blood colloid osmotic pressure are equal are 25

27
Q

what is reabsorption and where does it happen

A

at the venous end, net filtration pressure in -7 blood goes into the capillary since capillary hydrotatic pressure 18 is lower than blood colloidal osmotic pressure at 25

28
Q

how many rbc in 1 ml blood

A

5 x 10^9

29
Q

shape of tbc

A

flat, indented, disc shaped that flatten in the centre

30
Q

diameter of rbc

A

8um

31
Q

function of biconcave shape of rbc

A

provide larger SA for diffusion of O2 across membrane

32
Q

function of thinness of rbc

A

enables O2 to diffuse rapidly

33
Q

what traits of rbc helps trnapsortation of O2

A

biconcave
thin
lack ncleus (more O2)
flecible and pliable (squeese tight spaces)
haemoglobin (most important- carry O2)

34
Q

haemoglobin solubility

A

not soluble in plasma

35
Q

where is hemoglobin found

A

neurons, rbc, immune cells
270 mill per rbc

36
Q

what does hemoglobin consist of

A

globin
heme group

37
Q

glboin in hemoglobin

A

4 highly folded peptide chains- tetramer

38
Q

heem group

A

4 Fe containing, non protien groups each bound to a polypeptide

39
Q

Fe and O2 binding

A

each combines reversibly
4Fe=4O2
98.5% of O2 carried by hemoglobin

40
Q

arterial versus venous color

A

arterial is red
venous is blue

41
Q

what can hemoglobin bind to

A

CO2, H+, CO, NO
prefers CO 250x than O2 (CO poisoning)