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MicroBio Immunity > Immunity 1 and 2 > Flashcards

Immunity 1 and 2 Flashcards

Notes on the first and second line

1
Q

PRR exist even before encountering a specific bacteria

A

True

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2
Q

Inflammatory responses are general responses

A

true

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3
Q

characteristics of FUO

A

fever greater than 101 F
lasts longer that 3 weeks
cause is not determined in 1 week

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4
Q

IFN Alpha stimulates

A

phagocytosis

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5
Q

IFN Beta stimulates

A

phagocytosis

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6
Q

IFN Gamma are products of

A

T cells

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7
Q

IFN Alpha and Beta are products of

A

nmany cells including lymphocytes, ,fibroblasts and macrophages

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8
Q

IFN Gamma are

A

immune regulators of macrophages and T & B cells

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9
Q

Immune systems are responsible for

A

body survellience

recognition and destruction of foreign bodies

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10
Q

How many lines of defense are there

A

3

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11
Q

How many lines are innate?

A

1

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12
Q

What are the names of the innate and non specific lines of defense?

A

1st and second line

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13
Q

What are the major types first line defenses?

A

Physical barriers
chemical barriers
genetic components

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14
Q

System of protective cells and fluids that act w hen the first line is circumvented

A

Second Line of Defense (non-specific)

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15
Q

Second line Mechanisms

A

Phagocytosis
Fever
Inflammation
Antimicrobial Proteins

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16
Q

Functions of Phagocytes

A

survey tissues for targets
engulfment
Antigen extraction from foreign matter

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17
Q

Types of phagocytes

A 
neutrophiles
Macrophages
Dendritic Cells
Mast Cells
Eoisinophils
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18
Q

How many steps are in phagocytosis?

A

6

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19
Q

What are the steps for phagocytosis

A 
Chemotaxis
adhesion
engulfment
phagolysosome
Destruction
Elimination
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20
Q

What happens during Chemotaxis and adhesion

A

the phagocyte find the antigen and the antigen binds to the phagocytes MHC II receptor

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21
Q

The immunogen is taken into the phagocyte and is stored within a phagosome in the cytoplasm of the phagocyte

A

Engulfment

22
Q

Phagolysosome

A

The phagosome fuses with lysosome to kill the antigen

23
Q

Characteristics of inflammation

A

Rubor
Calor
Tumor
Dolor

24
Q

The site of inflammation appears red

A

Rubor

25
Q

The site of inflammation is experencing discomfort or pain

A

Dolor

26
Q

The sight of the infection is raised and seems full

A

Tumor

27
Q

The sight of the infection feels hot

A

Calor

28
Q

What can cause inflammation

A

Infection
Tissue injury
phys and chem agents
specific immune reactions

29
Q

Function of Inflammation

A

Mobilize and attract immune components
Start repair
Clear away antigenic substances
Destroy microbes and prevent further infection

30
Q

What are the stages of inflammation

A

INJURY
Vascular reaction
edema
Resolution

31
Q

how many steps are in there in the inflammation process

A

4

32
Q

What initiates Fever?

A

when pyrogens reset the hypothalamic thermostat to a a higher temperature

33
Q

what substance causes fever?

A

pyrogens

34
Q

Types of pyrogens

A

Exogenous and Endogenous

35
Q

substance comes from inside the body

A

endogenous

36
Q

substance comes from outside the body

A

exogenous

37
Q

what does fever reduce?

A

antigen reproduction
bacterial METABOLISM
Iron and Sugar availability

38
Q

What does fever increase?

A

Body temp

WBC count

39
Q

Types of antimicrobial proteins

A

INF
Complement
Iron-binding proteins (Siderphore)
Peptides (Defensin)

40
Q

What are the steps of Complement

A 
Initiation
Amplification
cascade
polmerization
membrane attack
41
Q

what is amplified by complement

A

inflammation

42
Q

what are 3 results of complement

A

Lysis
inflammation
opsonization

43
Q

the marking of cells or antigens for destruction

A

Opsonization

44
Q

What are markers made of

A

proteins and/or sugar

45
Q

What do markers distinguish

A

Self and nonself

46
Q

How many body body compartments are there?

A

4

47
Q

What are the body compartments?

A

Reticuloendothelial System
Lymohatic system
Extracellular Fluid
vascular system

48
Q

function of RES

A

provides passage btwn tissues and organs

49
Q

functions of the Lymphatic System

A

surveillance
recognition
protection
Drain for inflammatory reaction

50
Q

What can Cytokines do?

A

Mediation of nonspecific immune reactions and vasoactive reactions
regulate growth and activation of lymphocytes

MicroBio Immunity (5 decks)

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