Immunisation

Question 1

What are the advantages of live vaccines?

Answer 1

Single dose often sufficient to induce long-lasting immunity
Strong immune response evoked
Local and systemic immunity produced

Question 2

What are the disadvantages of live vaccines?

Answer 2

Potential to revert to virulence
Contraindicated in immunosuppressed patients
Interference by viruses or vaccines and passive antibody
Poor stability
Potential for contamination

Question 3

What are the advantages of inactivated vaccines?

Answer 3

Stable
Constituents clearly defined
Unable to cause the infection

Question 4

What are the disadvantages of inactivated vaccines?

Answer 4

Need several doses
Local reactions common 
Adjuvant needed 
keeps vaccine at injection site
activates antigen presenting cells
Shorter lasting immunity