Autoimmunity diagnosis

Question 1

What is the definition of sensitivity in this context?

Answer 1

[a/(a+c)]- measure of how good is the test in identifying people with the disease

Question 2

What is the definition of specificity in this context?

Answer 2

[d/(b+d)]- measure of how good is the test at correctly defining people without the disease

Question 3

What is a Positive predictive value?

Answer 3

[a/(a+b)]-The proportion of people with a positive test who have the target disorder

Question 4

What is a Negative predictive value?

Answer 4

d/(c+d) The proportion of people with a negative test who do not have the target disorder.

Question 5

What are the non-specific markers of systemic inflammation?

Answer 5

ESR
CRP
Ferritin
Fibrinogen
Haptoglobin
Albumin
Complement

Question 6

How is anti-dsDNA tested for?

Answer 6

Crithidia luciliae assay (protosoa)
Farr assay
ELISA assay

Question 7

How are ENA’s tested for?

Answer 7

Immunoblots
Individual ELISA’s
Combination of antigens

Question 8

Which is more specific for Rheumatoid arthritis - RF or ACPA?

Answer 8

ACPA (95% compared to 70%)

Question 9

What is the gold standard for diagnosis in most cases?

Answer 9

Histopathology

Question 10

What are some types of autoantibodies in type 1 diabetes?

Answer 10

islet cell antibodies
anti-GAD65 anti-GAD67
anti-insulinoma antigen 2 (IA-2)
insulin autoantibodies (IAAs)