Immune system VII - Monoclonal antibody formulation Flashcards
1
Q
Define polyclonal antiserum
A
Serum from another animal immunised against an antigen
2
Q
Why are monoclonal antibodies so unique?
A
More stable
Longer half life
Higher molecular weight
Higher doses
3
Q
Why are excipients added to preparations?
A
Reduce aggregation
4
Q
Name TWO future advances for monoclonal antibody formulation
A
Pre filled syringes
Reduce injection volume
5
Q
Name FOUR factors that affect immunogenicity
A
Type of biologic
Origin of biologic
Delivery
Formulation
6
Q
What is aggregation driven by? (2)
A
Incorrect storage
Denaturation
