Immune system IV - Hypersensitivity Flashcards
What is the difference between hypersensitivity and autoimmunity?
External source of antigen - hypersensitivity
Internal source of antigen - autoimmunity
What is the effector mechanism for class I hypersensitivity?
IgE antibody on mast cells causing histamine release
What is an example of class I hypersensitivity?
Anaphylaxis, hayfever, asthma
What is the effector mechanism for class II hypersensitivity?
IgM and IgG antibody mediated cell killing
What is an example of class II hypersensitivity?
Mismatched blood transfusion
What is the effector mechanism for class III hypersensitivity?
IgG antibody immune complexes
Give an example of class III hypersensitivity
Long term monoclonal antibody use
What is the effector mechanism for class IV hypersensitivity?
T lymphocytes
Give an example of class IV hypersensitivity
Contact dermatitis
What are the FOUR interventions for hypersensitivity?
Avoidance of antigen
Avoidance of priming via de-sensitisation
Suppression of antigen effector functions
Symptomatic relief
List some of the topical antihistamines available (3)
Cream - anti hisan
Nasal spray - rynacrom
Eye drops - opticrom
How do corticosteroids work?
Synthetic mimics of antiinflammatory steroid molecules
