Immune System and Malignancy Flashcards
What dose adjustments must be made when Azathioprine/Mercaptopurine is given together with Allopurinol?
Reduce Azathioprine/Mercaptopurine dose to 1/4 of normal dose
When is Ciclosporin contra-indicated? (2)
Renal impairment, malignancy
Treatment options for MS
Disease-modifying eg Glatiramer acetate
Interferons
Fungolimod
Immunomodulators eg Dimethyl Fumarate
Which condition can Fingolimod cause?
Progressive multifocal leukoencephalopathy (PML)
Most common/serious SEs of chemotherapy (6)
Extravasation necrosis
Tumour lysis syndrome
Oral mucositis
Hyperuricaemia
Bone marrow suppression
Nausea & Vomiting
Degrees of emetogenicity for chemo with examples
Mildly emetogenic: Fluorouracil, Methotrexate, Vinca alkaloids
Moderately emetogenic: Taxanes, Doxorubicin
Highly emetogenic: Cisplatin, High doses of Cyclophosphamide
Which chemo drugs are most commonly associated with oral mucositis? (3)
Fluorouracil, Anthracyclines, Methotrexate
Special side-effect of Cyclophosphamide to look out for and what is the treatment?
Haemorrhagic cystitis - increase fluid intake and give Mesna
What can be given to treat/prevent hyperuricaemia (2)
Allopurinol
Rasburicase
Main side-effect of doxorubicin
Cardiomyopathy
When is Fluorouracil contraindicated?
Bone marrow suppression (eg after radiotherapy)
Main SEs/toxicity areas of Methotrexate (4)
Bone marrow suppression
GI toxicity (mucositis 1st sign)
Liver toxicity
Pulmonary toxicity
Main SE of Bleomycin
Pulmonary toxicity
Main toxicity area of Cisplatin
Nephrotoxicity
What doe you need to do before giving Paclitaxel and why
Pre-medication with steroid + antihistamine + H2-antagonist to avoid hypersensitivity reaction
