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Blood and Lymph > Immune MDT > Flashcards

Immune MDT Flashcards

1
Q

What is an allergy?

A

Immunologically mediated hypersensitivity reaction to foreign antigen manifested by tissue inflammation and organ dysfunction

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2
Q

When will allergy reactions occur after initial exposure?

A

Immediately, generally within 60 minutes

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3
Q

What is anaphylaxis?

A

Most serious and potentially life threatening manifestation of mast cell and basophil mediator release

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4
Q

How is anaphylaxis clinically defined?

A

Acute onset of illness involving skin or mucosal tissue and either respiratory compromise or hypotension (SBP <90mm Hg or 30% less than known base line)

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5
Q

When will food allergy occur?

A

Within 2 hours of ingestion

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6
Q

When will medication allergy occur?

A

Within 30 minutes

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7
Q

What lab studies should be done for allergies?

A

Specific IgE serum or skin testing

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8
Q

How should you treat an allergic reaction?

A

Epinephrine 0.2-0.5mg SC or IM q5-15 minutes as needed to a max of 1mg

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9
Q

What other antihistamines may you give for allergic reactions?

A

Loratadine 10mg
Desloratadine 5mg
Fexofenadine 60mg or 120mg
Cetirizine 10mg

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10
Q

What is urticaria?

A

Allergen mediated rash, wheals or hives

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11
Q

How long is urticaria self limiting?

A

1-2weeks

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12
Q

How long does chronic urticaria last?

A

More than 6 weeks

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13
Q

Urticaria’s most common immunologic mechanism is?

A

IgE

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14
Q

What is angioedema?

A

Swelling of vascular tissue involving deeper subcutaneous tissue with swelling of lips, eyelids, palms, soles and genitalia

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15
Q

What are triggers of angioedema?

A

NSAIDS
ACEi
Estrogens
ASA
CCB
Amiodarone

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16
Q

What is lupus?

A

Multisystem autoimmune disease

17
Q

Where will a patient with lupus develop a rash?

A

Areas exposed by sunlight, classically is a malar rash

18
Q

Systemic Sx of SLE

A

Fever, anorexia, malaise and weight loss
Malar “butterfly”
Alopecia
Mucus membrane lesions
Joint sx

19
Q

Respiratory sx of SLE

A

pleurisy, effusion, bronchopneumonia, pneumonitis

20
Q

Cardiac sx of SLE

A

Pericardium, myocarditis, hypotension, arrhythmias

21
Q

Neuro sx of SLE

A

Psychosis, cognitive impairment, seizures, impairment, peripheral and cranial neuropathies, transverse myelitis and strokes

22
Q

What lab study should be done for SLE?

A

Antinuclear antibody tests are nearly 100% sensitive for SLE but not specific

Blood and Lymph (6 decks)

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