Immune Function Testing Lecture Powerpoint Flashcards
8/28/19
Who should be tested for immune functioning?
- Adults/pediatric patients with recurrent infections that consistently get sick and cannot get over it
- Those with opportunistic infections
- those with suspicion of or family history of immune deficiency disease
Complement plays a role in both ___ and ____
innate and adaptive immunity
Most common type of WBC in blood stream
Neutrophil
Eosinophils target ___ cells and play a role in ___. They do not respond to ____
large cells too big for ingestion, allergies, viral infection
Baophils do not ____ foreign cells, play a role in ___, and do not respond to ____
ingest, allergies, viral infection
Natural killer cell function
Recognize and attach to infected cells or cancer cells regardless of MHC and damage the outer membranes as part of the innate defense
Classical pathway of complement activation
Antibody binds to and exposes complement binding sites on the foreign cell invader, complement proteins then for the membrane attack complex to tear cell apart
Alternative pathway of complement activation
Directly binds to the polysaccharides of microbial cell walls and forms the membrane attack complex to tear cell apart
What is the common protein between the classical and alternative pathway of complement activtation? Why is this one extra important to measure?
C3, it allows assessment of both classical and alternate pathways
Interferons
A type of cytokine that interferes with the reproduction of viruses
Screening test for innate granulocytes
CBC with diff (lab analysis) and peripheral blood smear (microscopic observation)
Screening test for complement
Serum total hemolytic complement (TCH50 or CH50)
Critical values for WBC count
2500
Pancytopenia
Decrease in all blood cell lines (WBC and RBC)
Leukopenia
Decrease in WBC count