Immune 4

Question 1

Humoral immunity

Answer 1

CD4 MCH2 extrinsic results in B cells

Question 2

Cellular immunity

Answer 2

CD8 MHC intrinsic results in cytokines

Question 3

A kind of membrane molecules on T cells that can specially bind to
the antigenic peptide-MHC molecule complex

Answer 3

T cell receptors TCR

Question 4

on resting or  activated T cells binds to the B7 sends a stimulatory signal

Answer 4

CD28

Question 5

on  activated T cells. Bind to B7 Transmit an inhibitory signal to T cells

Answer 5

CTLA-4

Question 6

LFA-2, Sheep red blood cell receptor)
Expressed on 90% mature T cells (none on B cells)
Its ligand is CD58 (LFA-3) expressed on APC, RBC of human or sheep

Answer 6

CD2

Question 7

1) Formation of E-rosece
2)   Enhance the binding of TCR and anti-genic peptide-MHC molecule complex
3)   Participate in signal transduction of T cell  activation

Answer 7

CD2

Question 8

Present on  activated TH cells
Involved in activation  of B cells
Bind to CD40L molecules on APCs

Answer 8

CD40

Question 9

Antigen-dependent differentiation in lymphoid tissues (to become memory and effector T cells)

Answer 9

Primary phase in T CELLS

Question 10

Migration to sites of infection and effector function

Answer 10

Effector phase on T cells

Question 11

Acquire specific receptors eg TCR , colonial selection, double positive cell happens@

Answer 11

Outer cortex of thymus

Question 12

Central self tolerance, TCRs recognize MHC, loaded with normal self-peptides (p-MHC) @

Answer 12

Medulla of thymus

Question 13

TCR w LOW affinity to p-MCH

TCR that bind too strongly to pMHC

Answer 13

A)will receive positive selection signals to
divide and establish clones
B) undergo (negative selection)

Question 14

Activate macrophages, NK cells and CTLs 3)  Enhance production of selected classes of Abs that participate in
 opsonization and ADCC
During it made me innate activates NK and macrophages 

Answer 14

TH1

Question 15

IFN-γ and IL-2

Answer 15

Increase TH1 and inhibit TH2

Question 16

IL-4 and IL-10

Answer 16

Increases TH2 inhibits TH1

Question 17

recognize antigen on surface of target cells (infected APC or other
infected nucleated cell) in association with MHC-I They are activated and kill the virus infected cell or tumour cell , 35% of T cells

Answer 17

CD8 cytotoxic

Question 18

———- infection is mediated by: ABs complement and macrophages

Answer 18

Extra cellular

Question 19

——-may play a role in some harmful condi8ons:

Hypersensitivity , graft resection and autoimmune diseases

Answer 19

Cell mediated immunity

Question 20

act as signal transduction molecules

Answer 20

 CD3, CD4, and CD8

Question 21

production of specific clones of effector T cells and memory clones. develops in several days does not limit the infection

Answer 21

Primary response

Question 22

Class of bacterial toxins (staphylococcal enterotoxins) & retroviral proteins that can activate very large number of T cells irrespective of their antigen specificities.

Answer 22

Super antigens

Question 23

1. Not processed
2.   Interact with the MHC class II molecule outside of the peptide- binding
   groove.
   3.  Bind only to the V
   β
   segment of TCR.

Answer 23

Super Ags

Question 24

From T cells, Proliferation and/or activation of T & B cells

Answer 24

IL-2

Question 25

From T-B-mast cells, Activation of B cells, differentiation

of Th2 cells

Answer 25

IL-4

Question 26

From T-B - macrophages, Suppression of macrophages,

activation of B cells

Answer 26

IL-10

Question 27

From T cells, antiviral activity

Answer 27

IFN γ

Question 28

Clonal selection + double positive cells @

Answer 28

Outer cortex of the thymus