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Renal II > IMM 1 immunological aspects of the renal system > Flashcards

IMM 1 immunological aspects of the renal system Flashcards

1
Q

IMPAIRMENT OF KIDNEY FILTRATION IS ACTIVATED BY?

ARF defined as?

Major cause of ARF?

this is how common?

A
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2
Q

NKD?

AKI?

CKD?

A
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3
Q

causes of kidney hypoperfusion and AKI?

all lead to what?

which leads to?

in most Cases, cause of AKI is not what but instead what?

A
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4
Q

sterile renal inflammation is induced by?

released by?

bind? to activate what?

what can recognize them? via?

A
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5
Q

PAMPS and DAMPS

inducers?

sensors?

mediators?

A
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6
Q

immune cells-mediated mechanisms of kidney injury

ultimately cause?

A
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7
Q

early stages immune responses mediated by?

later stages?

M1 vs M2?

A
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8
Q

M1 activated by?

M2?

ultimately cause?

A

M1 causes direct tubular injury

M2 cause repair of AKI

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9
Q

TH1, 2, 17

cause what?

A
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10
Q

Role of Th17 cells in AKI?

secrete what?

this causes?

may recruit what else by release of?

this causes?

A
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11
Q

complement role in inflammation and recruitment?

A
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12
Q

type II/III hypersensitivity in kidney injury?

A
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13
Q

end-stage organ failure what do you do?

barrier to this?

methods to prevent?

HVGR?

GVHR?

A
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14
Q

classification of grafts?

classified on what?

4 types of grafts?

oddest one what increases chance of success?

A
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15
Q

these variables determine transplant outcome?

A
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16
Q

cascade of allograft rejection?

A
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17
Q

NOn-immunological factors

(condition of allograft)

types?

when transplanted (damaged graft) what happens?

A
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18
Q

Matching donor and recipient

A
  1. Blood Group Antigens (ABO): Matching Donor and Recipient
  2. Testing for Pre-Existing non-ABO Abs(anti-class I/II HLA abs)
  3. HLA: Matching Donor & Recipient
  4. TESTING FOR CLASS I HLA COMPATIBILITY
    1. not important for non-vascularized tissues
  5. TESTING CLASS II HLA COMPATIBILITY
    1. SAME AS 4
19
Q

blood group antigens (ABO) matching

barrier to transplantation of?

what antibodies?

not important in what transplantations?

A
20
Q

in the different blood types what type of Abs and Ags present who can donate to them?

A
21
Q
A
22
Q

Testing for pre-existing non-ABO Abs

(anti-class I/II HLA abs)

what is it not important for?

A

Non-vascularized tissues transplants

cornea, heart valves, bone

23
Q

Microcytotoxicity test for preformed Abs?

A
24
Q

HLA: matching donor and recipient

success dependent on?

encoded by?

compatibility required due to?

A
25
Q

how many allelic forms of HLA molecules?

each inherits how many?

dominant? recessive?

Class-I?

Class-II?

A
26
Q

Testing for class I HLA compatibility

serological class I HLA typing

identification of HLA Ags normally dependent on what?

A

Not important for non-vascularized tissues

  • Cornea
  • Heart valves - Bone
27
Q

MIcrotoxicity test (class I MHC)

A
28
Q

which would match and not match?

A
29
Q

TESTING CLASS II HLA COMPATIBILITY

what test?

what do you do?

how do you tell match vs non match?

A

Not important for non-vascularized tissues

  • Cornea
  • Heart valves - Bone
30
Q

Two Types of Immune Responses in Transplantation?

A
31
Q

Host versus graft response

what attacks what?

what type of immune response?

stronger or weaker than normal response?

why?

immune memory?

A
32
Q

direct vs indirect allorecognition

cells from what?

A
33
Q

Host versus graft response

how much of host T cells recognize single foreign MHC?

what can activate what (causing problems)

this causes?
types of effector mechanisms of graft rejection?

A
34
Q
A
35
Q

mechanisms of rejections

the three type of host vs graft

what will cause problem?

A
36
Q

hyperacute graft rejection

how long? from what point?

caused by?

what can lead to death of what?

A
37
Q

acute graft rejection

how long? initiated by?

plays an important role?

why?

damage happens how?

what can cause rejection?

A
38
Q

chronic graft rejection

occurs in what time?

due to?

main pathogenic mechanism is?

non-immunologic factors to chronic rejection include?

doesnt respond to?

A
39
Q

Graft-versus-host disease

caused by?

reaction directed against?

occurs in?

why?

types (solid grafts) of GVHD?

A
40
Q

GVHD

what is Ag?

what is APC?

what allows donor CD8 to react?

A
41
Q

Two effector mechanisms of GVHD?

A
42
Q

Treg cells in AKI?

A
43
Q

AKI and CKD disease modifiers?

risk factors?

outcomes?

A

Renal II (8 decks)

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