IMM 1 immunological aspects of the renal system Flashcards
IMPAIRMENT OF KIDNEY FILTRATION IS ACTIVATED BY?
ARF defined as?
Major cause of ARF?
this is how common?
NKD?
AKI?
CKD?
causes of kidney hypoperfusion and AKI?
all lead to what?
which leads to?
in most Cases, cause of AKI is not what but instead what?
sterile renal inflammation is induced by?
released by?
bind? to activate what?
what can recognize them? via?
PAMPS and DAMPS
inducers?
sensors?
mediators?
immune cells-mediated mechanisms of kidney injury
ultimately cause?
early stages immune responses mediated by?
later stages?
M1 vs M2?
M1 activated by?
M2?
ultimately cause?
M1 causes direct tubular injury
M2 cause repair of AKI
TH1, 2, 17
cause what?
Role of Th17 cells in AKI?
secrete what?
this causes?
may recruit what else by release of?
this causes?
complement role in inflammation and recruitment?
type II/III hypersensitivity in kidney injury?
end-stage organ failure what do you do?
barrier to this?
methods to prevent?
HVGR?
GVHR?
classification of grafts?
classified on what?
4 types of grafts?
oddest one what increases chance of success?
these variables determine transplant outcome?
cascade of allograft rejection?
NOn-immunological factors
(condition of allograft)
types?
when transplanted (damaged graft) what happens?
Matching donor and recipient
- Blood Group Antigens (ABO): Matching Donor and Recipient
- Testing for Pre-Existing non-ABO Abs(anti-class I/II HLA abs)
- HLA: Matching Donor & Recipient
- TESTING FOR CLASS I HLA COMPATIBILITY
- not important for non-vascularized tissues
- TESTING CLASS II HLA COMPATIBILITY
- SAME AS 4
blood group antigens (ABO) matching
barrier to transplantation of?
what antibodies?
not important in what transplantations?
in the different blood types what type of Abs and Ags present who can donate to them?
Testing for pre-existing non-ABO Abs
(anti-class I/II HLA abs)
what is it not important for?
Non-vascularized tissues transplants
cornea, heart valves, bone
Microcytotoxicity test for preformed Abs?
HLA: matching donor and recipient
success dependent on?
encoded by?
compatibility required due to?
how many allelic forms of HLA molecules?
each inherits how many?
dominant? recessive?
Class-I?
Class-II?
Testing for class I HLA compatibility
serological class I HLA typing
identification of HLA Ags normally dependent on what?
Not important for non-vascularized tissues
- Cornea
- Heart valves - Bone
MIcrotoxicity test (class I MHC)
which would match and not match?
TESTING CLASS II HLA COMPATIBILITY
what test?
what do you do?
how do you tell match vs non match?
Not important for non-vascularized tissues
- Cornea
- Heart valves - Bone
Two Types of Immune Responses in Transplantation?
Host versus graft response
what attacks what?
what type of immune response?
stronger or weaker than normal response?
why?
immune memory?
direct vs indirect allorecognition
cells from what?
Host versus graft response
how much of host T cells recognize single foreign MHC?
what can activate what (causing problems)
this causes?
types of effector mechanisms of graft rejection?
mechanisms of rejections
the three type of host vs graft
what will cause problem?
hyperacute graft rejection
how long? from what point?
caused by?
what can lead to death of what?
acute graft rejection
how long? initiated by?
plays an important role?
why?
damage happens how?
what can cause rejection?
chronic graft rejection
occurs in what time?
due to?
main pathogenic mechanism is?
non-immunologic factors to chronic rejection include?
doesnt respond to?
Graft-versus-host disease
caused by?
reaction directed against?
occurs in?
why?
types (solid grafts) of GVHD?
GVHD
what is Ag?
what is APC?
what allows donor CD8 to react?
Two effector mechanisms of GVHD?
Treg cells in AKI?
AKI and CKD disease modifiers?
risk factors?
outcomes?
