ILD Flashcards
Is pulmonary fibrosis malignant?
no
what two ILDs do clubbing occur in?
idiopathic pulmonary fibrosis and asbestosis
On chest x ray - irregular, reticulo-nodular shadows, often in lower zones?
pulmonary fibrosis
what zone of the lungs does IPF usually occur?
lower
what is the prognosis of IPF?
most patients die within 5 years
what is Pneumoconioses?
A group of disorders caused by inhalation of mineral or biological dusts.
what is Simple pneumoconiosis ?
Coal dust deposition within the lung
histology of asbestosis?
features of pulmonary fibrosis and honeycomb lung, affecting the lower lobes more commonly
which antigens cause Extrinsic Allergic Alveolitis?
- mouldy hay (farmers lung)
- bird faeces (bird fanciers lung)
- cotton fibres (byssinosis)
- sugar cane fibres (bagassosis)
farmers lung - which type of immune complex reaction?
type 3 (fork)
what is good pastures syndrome?
Glomerulonephritis and respiratory symptoms
3 features of good pastures?
haemoptysis, haematuria and anaemia
what type of immune hypersensitivity in gps?
type 2
which antibody is found circulating in GPS?
anti basement membrane. This causes glomerulonephritis and acts on alveolar membranes
what initial appearance would you see on x ray then at later stages in IPF?
ground glass appearance then honeycombing
what is the management of IPF?
very few medications have been shown to give any benefit in IPF. There is some evidence that pirfenidone (an antifibrotic agent) may be useful in selected patients (see NICE guidelines)
what is the most common form of asbestos related lung disease and generally occurs after a latent period of 20-40 years?
benign pleural plaques
Asbestosis typically causes fibrosis in which lobe?
lower
latent period in asbestosis?
15-30 years
