GI tutorial - PBC, PSC Flashcards
40 year old woman with itch and raised ALP. No gallstones?
PBC
which sex get PBC?
women
what is the pathophysiology?
autoimmune destruction of the small bile ducts. This causes cholestasis.
in terms of diagnosis of PBC, which highly sensitive antibodies are raised and serum Ig? is raised?
Ferocious. Mum. Anti microbial antibodies 98% specific and IgM
why does damage of interlobular bile ducts cause cirrhosis?
bile damages liver
what is the management of the itch?
cholestyramine (SCOM)
what is the main treatment of PBC?
ursodeoxycholic acid (ursula)
Which enzyme in liver function test is raised in alcoholic liver disease?
AST S= strawpaedo
which enzyme is the most specific in LFTs ?
ALT L=LIVER
which is a marker of alcohol usage?
GGT G G&T
why is thrombocytopenia associated with hypersplenism?
platelets pool in large spleen
why does liver cirrhosis cause splenomegaly?
splenic vein drains straight into liver
how does titration of ANA work?
the higher the bottom number, the more antibody present, i.e. the more times it can be diluted
what is a risk of ERCP?
pancreatitis (5% risk)
what is used to reverse paracetamol overdose?
n acetyl cysteine
