II generation antihistamines

Question 1

Drugs of the 2 generation

Answer 1

Loratadine
Ebastin
Acrivastine

Question 2

Pharmacologically active metabolites

Answer 2

Cetirizine

Desloratadine

Question 3

Indications for administration of antihistamines of II and III generations

Answer 3

1) Seasonal (pollinosis) and perennial allergic rhinitis.
2) Itchy dermatosis (atopic dermatitis, eczema, chronic recurrent urticaria
3) Chronic idiopathic urticaria

Question 4

H1-histamine blockers with membrane stabilizing properties

Answer 4

Ketotifen

Question 5

Ketotifen

Answer 5

treatment of seasonal and year-round allergic rhinoconjunctivitis, atopic dermatitis; prevention of asthma attacks, asthmatic complications during pollinosis, exacerbations of allergic dermatosis.

Question 6

Ketotifen Mechanism of action :

Answer 6

• Inhibition of phosphodiesterase,
• reduction of biodegradation of 3,5-cAMP and its accumulation in the cell
• mild blocking of H1-histamine receptors
• reduces the content of eosinophils in the respiratory tract
• Inhibits platelet activating factor

Question 7

Ketotifen Indications

Answer 7

• bronchial asthma (prevention of seizures)
• pollinosis (prevention of asthmatic complications)
• allergic dermatosis
• allergic rhinoconjunctivitis

Question 8

Ketotifen Unwanted side effects

Answer 8

• CNS depression
• dry mucous membranes (feeling of dry mouth)
• Thrombocytopenia

Question 9

Ketotifen Contraindications

Answer 9

• for persons whose professional activity requires attention and high speed of sensorimotor reactions
• pregnancy and lactation