I generation antihistamine

Question 1

Drugs

Answer 1

Diphenhydramine
Mecvitasine
Clemastine
Hifenadine

Question 2

Diphenhydramine Pharmacological effects

Answer 2

Antihistime
Antihemetic
Antispasmodic
Sedative
Hypnotic
Local anesthetic
Acethyl choline blocker

Question 3

Diphenhydramine Side Effects

Answer 3

Drowssiness
visual impairment
general weakness
numbness of mucous membrane of oral cavity
bladder dysfunction
bronchospasm 
tackycardia 
skin rashes
increase appetite & gain weight
dizzyness & headache
decrease peripheral vasodilatation

Question 4

Diphenhydramine Contraindications

Answer 4

1) work requiring mental & motor activity attention
2) Disease: asthma, peptic ulcer, urinary retention, hyperplasia, cardiovascular disease
3) Pharmacological incompatibility with drugs: anticonvulsant, antipsychotics, MAO inhibitors, agents for parkinson & diabetes, antidepresants

Question 5

Diphenhydramine Indications

Answer 5

Allergic rhinitis
Allergic conjunctivitis
Atopic dermatitis (skin disease)
Allergic to insects bite & stings
Insomnia
Parkisonism
Vomiting in pregnant

Question 6

for topical application drugs

Answer 6

Azelastine (nasal)

Levocabastin (eye drops)

Question 7

for topical application drugs Advantage

Answer 7

• no side effect
• rapid onset
• easy achival of high local concentration of drugs in mucous membrane

Question 8

for topical application drugs Disvantage

Answer 8

rarely irritability of conjuntiva or nasal mucosa

Question 9

mecanism of action

Answer 9

Anti-inflammatory effect of H 1-antihistamine. H 1-antihistamines directly inhibit the action of histamine through H 1-receptors on neuron and small vessels.