Glucocorticoids

Question 1

Mechanism of action :

Answer 1

• inhibit the antigen presenting function of macrophages
• inhibit the proliferation of B-lymphocytes, reduce plasma tissue
• have a weak inhibitory effect on antibody production and the formation of the CIC
• stabilize the membranes of mast cells and basophils (partly due to inhibition phospholipases A2), and also reduce their degranulation
• have anti-shock effect
• have anti-inflammatory effect

Question 2

Indications :

Answer 2

• bronchial asthma
• skin diseases with an allergic component (severe allergic dermatitis, eczema, psoriasis, neurodermatitis)
• allergic rhinoconjunctivitis
• anaphylactic shock, serum sickness

Question 3

Glucocorticoids used topically for allergic rhinitis

Answer 3

Mometasone
Beclomethasone
Triamcinolone
Fluticasone

Question 4

Glucocorticoids used topically for allergic dermatitis

Answer 4

Triamcinolone

Fluocinolone acetonide