ID-Quinolone and Macrolides

Question 1

What do the respiratory FQs levo and moxi cover?

Answer 1

strep pneumo
Atypicalswh

Question 2

which FQs cover Pseudomonas and UTI and traveller’s diarrhea

Answer 2

Levo and Cipro

Question 3

which FQ must be avoided in UTI

Answer 3

Moxifloxacin

Question 4

what is a BW for FQs

Answer 4

1. tendon rupture and inflammation
2. peripheral neuropathy
3. Seizure
4. CNS effects

Question 5

what is a major WARNING for FQs

Answer 5

QT prolongation especially with other QT prolonging agents
-Macrolides
-Azoles
-Methadone
-Antipsychotics

Question 6

when should FQ be avoided

Answer 6

children and pregnancy

Question 7

What is another major warning of FQs

Answer 7

-psychiatric disturbances -delirium and agitation
-photosensitivity

Question 8

Can Cipro be put in a feeding or NG tube?

Answer 8

No

Question 9

what is the standard doe for Azithro?

Answer 9

Z-PAk is 500 mg on day 1 and 250 mg on day 2-5

Tri-PAk is 500 mg daily for 3 days

Question 10

when is clarithromycin used mostly

Answer 10

H.Pylori therapy (prevpac)

Question 11

What 2 macrlides are CI when taking simvastatin and lovastatin?

Answer 11

Erythomycin
Clarithromycin
- both inhibit CYP3A4

Question 12

when is another indication for erthyromycin

Answer 12

gastroparesis - gut motility

Question 13

what is a MAJOR warning with macrolides

Answer 13

QT Prolongation
hepatotoxic

Question 14

what is covered with macrolides and when are they used

Answer 14

-atypicals
-H.influenzae
-Strep pneumo

**CAP
**STI such as chlamydia
**URTI and LRTI

Question 15

what DDI must be avoided when taking FQs?

Answer 15

DDI with divalent cations such as Ca, Mg (present in antacids)