ID- Tetracyclines and SMX/TMP Flashcards

1
Q

when are tetracyclines used in therapy

A

CA-MRSA skin infection
H.Pylori
Acne
Atypicals
Rickettsiae –> tick infection
COPD exacerbabtions, VRE, UTI, STIs

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2
Q

which tetracycline does not require renal dose adjustment

A

Doxycycline

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3
Q

when must Tetracyclines be avoided

A

children < 8

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4
Q

what are 3 warning associated with tetra cyclines

A

photosensitivity
pregnant and breastfeeding
drink 8 oz of water and sit upright after each dose to avoid esophagus irritation

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5
Q

what is the main DDI associated with tetracyclines

A

Divalent cations

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6
Q

which ABx must be avoided in pregnancy

A

tetracyclines
FQs
Metronidazole

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7
Q

What is the difference between the DS and the SS formulation of Bactrim

A

SS is 400 SMX/80 mg TMP
DD is 800 SMX/160 mg TMP

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8
Q

what is the correct ratio of SMX/TMP for bactrim

A

5:1 always

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9
Q

when must Bactrim be avoided

A

Sulfa allergy

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10
Q

what are the 4 most important warning associated with Bactrim

A
  1. Photosensitivity
  2. Inc K+ levels
    • coombs test
  3. G6PD deficiency hemolytic anemia
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11
Q

what ABx can cause photosensitivity

A

Bactrim
Tetracyclines
FQs

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12
Q

what 2 ABx can cause inc INR with warfarin therapy due to inhibition of CYP2C9

A

Bactrim
Metronidazole

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13
Q

what is Bactrim compatible with?

A

Dextrose only

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14
Q

what ABx cover atypicals

A

respiratory FQs (levo and moxi)
Tetracyclines
Macrolides

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