ID- Tetracyclines and SMX/TMP Flashcards
when are tetracyclines used in therapy
CA-MRSA skin infection
H.Pylori
Acne
Atypicals
Rickettsiae –> tick infection
COPD exacerbabtions, VRE, UTI, STIs
which tetracycline does not require renal dose adjustment
Doxycycline
when must Tetracyclines be avoided
children < 8
what are 3 warning associated with tetra cyclines
photosensitivity
pregnant and breastfeeding
drink 8 oz of water and sit upright after each dose to avoid esophagus irritation
what is the main DDI associated with tetracyclines
Divalent cations
which ABx must be avoided in pregnancy
tetracyclines
FQs
Metronidazole
What is the difference between the DS and the SS formulation of Bactrim
SS is 400 SMX/80 mg TMP
DD is 800 SMX/160 mg TMP
what is the correct ratio of SMX/TMP for bactrim
5:1 always
when must Bactrim be avoided
Sulfa allergy
what are the 4 most important warning associated with Bactrim
- Photosensitivity
- Inc K+ levels
- coombs test
- G6PD deficiency hemolytic anemia
what ABx can cause photosensitivity
Bactrim
Tetracyclines
FQs
what 2 ABx can cause inc INR with warfarin therapy due to inhibition of CYP2C9
Bactrim
Metronidazole
what is Bactrim compatible with?
Dextrose only
what ABx cover atypicals
respiratory FQs (levo and moxi)
Tetracyclines
Macrolides