ID-PCNS Flashcards
Background on pathogens
What are the most resistant pathogens?
Kill Each And Every Strong Pathogen
Klebsiella
E.coli
Acinetobacter
Enterrobacter
Staphy (MRSA)
Pseudomonas
What ABx has a BW for C.diff?
Clindamycin
What common ABx have a IV:PO ratio of 1:1?
Lipophillic Agents
- Quinolones Levo and Moxi
-Tetracyclines
-Linezolid
**Metronidazole
What ABx follows a conc-dependent killing style?
Aminoglycosides
What ABx follow time dependent killing
All beta-lactams
As a class, what do PCNS cover?
Gram + enterococcus (except nafcillin and oxacillin)
As a class what does the PCNS not cover?
Atypicals and MRSA
What group of PCNS cover HNPEK
Aminopenicillins and the combo Unasyn and Augmentin
What PCN is considered to be extended spectrum with beta-lactamase inhibitor and is used for Pseudomonas and SPACE?
Zosyn –> given IV only –> extended infusion usually 3.375 grams for 4 hours
Which PCNs must be given IM only?
PCN G benzathine (bicillin L-A)
–> risk of cardiorespiratory death
–> used for syphillis
What ABx lowes seizure threshold?
PCNs,** Carbapenems, Cephalosporins and Quinolones
What are the ABx that cause hemolytic anemia through +Coombs test?
- sulfonamides (Bactrim)
-isoniazid
-rifampin
-PCNs
-Cephalosporins
What ABx cuase hemolytic anemia through G6PD deficiency?
-Dapsone
-Nitrofurantoin
-Sulfonamides (bactrim)
What is the use of the antistaphylococcals (nafcillin and oxacillin -IV) and dicloxacillin (PO)
-MSSA soft tissue
Which PCN has no renal dose adjustment?
Anti staphylococcal
-Nafcillin (IV)–> vesicant , risk of extravastaion
-Oxacillin (IV)
-Dicloxacillin (PO)
