ID-Cephalosporins

Question 1

What is a class effect with coverage in Cephalosporins?

Answer 1

Gram - coverage increases with each generation, no activity against enterococcus or MRSA

Question 2

What are the 1st Gen agents and their coverage?

Answer 2

1. Cefazolin (IV) for surgical prophylaxis and MSSA
2. Cephalexin PO for strep throat MSSA

Question 3

What are the 2nd Gen agents and their coverage?

Answer 3

1. Cefotetan and cefoxitin - IV/IM and will cover B.fragilis
2. Cefuroxime is IV and PO for CAP, AOM and sinusitis

Question 4

which Cephalosporin does not require renal adjustments? and what is it used for?

Answer 4

Ceftriaxone IV/IM

–> used for CAP, SBP, pyelonephritis
–>CI in neonates

Question 5

Which cephalosproin is used to treat pseudomonas?

Answer 5

**3rd Gen group 2 –> Ceftazidime and the combo ceftazidime with avibactam

** 4th Gen –> cefepime

Question 6

what are the 3 gen agents in group 1?

Answer 6

Group 1 –> Cefdinir PO, CTX IV/IM and Cefotaxime

Question 7

What are the 3rd Gen agents in group 2?

Answer 7

Ceftazidime

Question 8

What is the only Cephalosporin used to treat MRSA

Answer 8

Ceftaroline in Gen 5

Question 9

What are some AEs of Cephalosporins

Answer 9

Seizures
GI upset
+ Coombs test hemolytic anemia

Question 9

Which Cephalosporin cuases a disulfiram reaction when taken with alcohol

Answer 9

Cefotetan - Gen 2

Question 9

Which Cephalosporin and the Gen, must not be refrigerated

Answer 9

Cefdinir –> 3rd Gen