ID/Immunology

Question 1

Chediak-Higashi

Answer 1

Caused by abnormal neutrophil degranulation, leading to partial oculocutaneous albinism, nystagmus, peripheral neuropathy, and recurrent infections

Question 2

Chronic granulomatous disease

Answer 2

Abnormal phagocytic microbial ability, leading to increase risk of abscesses poor wound healing, and granuloma formation

Question 3

Job syndrome

Answer 3

Abnormal neutrophil chemotaxis leading to recurrent infections, also known as hyperimmunglobulin E syndrome

Question 4

Type of precautions for: CMV

Answer 4

Standard

Question 5

Type of precautions for: rubella

Answer 5

Contact, droplet

Question 6

Type of precautions for: HSV

Answer 6

Contact

Question 7

Type of precautions for: toxoplasmosis

Answer 7

Standard

Question 8

Type of precautions for: HIV

Answer 8

Standard

Question 9

Type of precautions for: tuberculosis

Answer 9

Airborne, contact

Question 10

Type of precautions for: varicella

Answer 10

Airborne, contact

Question 11

Type of precautions for: RSV

Answer 11

Contact

Question 12

Type of precautions for: parvovirus

Answer 12

Droplet

Question 13

Type of precautions for: listeria

Answer 13

Standard

Question 14

Can freezing milk and pasteurization reduce CMV transmission

Answer 14

Yes

Question 15

Does treatment with valganciclovir and CMV reduce risk of hearing loss

Answer 15

Yes

Question 16

By what postnatal age does maternal IgG typically disappear in the neonatal circulation

Answer 16

Nine months

Question 17

Rate of learning and visual disabilities and infants with congenital toxoplasmosis

Answer 17

Up to 80%

Question 18

Limb hypoplasia with cicatricial scarring is characteristic finding of what syndrome

Answer 18

Congenital varicella

Question 19

When does IgA production begin

Answer 19

At birth

Question 20

Order of activation in the classical pathway for complement

Answer 20

C1, C4, C2, and C3

Question 21

The classical and alternative pathways for complement converge at what

Answer 21

C3

Question 22

What is the most common compliment deficiency?

Answer 22

C2

Question 23

Deficiency of the late complement components (C5-C9) these to an increase risk of what

Answer 23

Neisseria infections

Question 24

Deficiency of the early components of the complement system (C1-C4) lead to an increased risk of what

Answer 24

Infections (especially pneumococcal) and collagen vascular disease

Question 25

Placental findings in CMV infection

Answer 25

Villous damage with thrombosis and villitis with some villi containing inclusion body cells and hemosiderin deposits

Question 26

Placental findings in syphillis

Answer 26

Hydrops and a marked round cell infiltration caused by maternal immunocytes

Question 27

Treatment of atypical complete DiGeorge syndrome

Answer 27

Immunoreconstitution with thymus transplantation; while waiting for transplant, they may require systemic corticosteroids to suppress the oligoclonal t-cells

Question 28

Mutation in leukocytes adhesion deficiency type 1

Answer 28

Beta-2 integrin gene (ITGB2)

Question 29

What are the inclusions in red cells of people without spleens

Answer 29

Howell jolly bodies

Question 30

Biggest risk factors for clabsi

Answer 30

Gestational age and birth weight

Question 31

Most common pathogens for early onset sepsis in order

Answer 31

GBS, E. coli, other strep species, enterococcus, staph aureus, listeria

Question 32

Most common complication of untreated asymptomatic congenital toxoplasmosis

Answer 32

Chorioretinitis

Question 33

Skin, vesicles, or scarring, present birth, chorioretinitis identified within the first week after birth, microphthalmia, microcephaly, abnormal brain CT findings identified within the first week after birth

Answer 33

Intrauterine HSV