ID Flashcards
What is the most likely causative organism:
18 mo girl presenting with warm tender knee joint following URTI
Joint aspiration shows gram negative
Kingella kingae
What is the vector for plasmodium falciparum?
Anopheles mosquito
What is the vector for Leishmania donovani?
Lutzomyia sandfly (phlebotomine)
What is the vector for schistosoma mansoni?
Biomphalaria glabrata snail
Which antibiotic is the commonest cause of C. difficile?
Amoxycillin
What is the bug - child on ALL chemo with neurological signs - csf stain in India Ink shows halos
Cryptococcus neoformans
Name three gram positive organisms - and whether rods, cocci
Strep pneumoniae - gram pos cocci Staph aureus - gram pos cocci Listeria - gram pos rod Clostridium - gram pos anaerobe Enterococcus - gram pos cocci
Name 5 gram neg aerobic organisms
Neisseria meningitides Morhaxella cattharlis Haemophilus influenzae Pseudomonas aeriginosa Bordetella pertussis
Name 5 gram negative facultative anaerobes
E. coli Salmonella Enterobacter Klebsiella pneumoniae Shigella Vibrio cholera
What is the mechanism of action of beta lactams
Bind specific penicillin binding proteins
Inhibits transpeptidase
Causes destruction of peptidoglycan cell wall — bacterial cell lysis
What is the mechanism of action of vancomycin. ?
Prevents cell wall synthesis - prevents incorporation of peptides into peptidoglycan cell wall
What are the 4 classes of protein synthesis inhibitors ?
Macrolides
Aminoglycosides
Tetracyclins
Chloramphenicol
What organism should you suspect with a conjunctival epidermal swab showing intracytoplasmic inclusions?
Chlamydia
Treatment = erythromycin
What immune defect should you suspect 1 yr old Cellulitis HSV gingival bleeding Small tonsils no LN Bloods show neutropenia Normal numbers T and B cells Low IgG and IgA
Hyper IgM syndrome
Often have neutropenia
What gene defect causes X linked hyper IgM ?
CD40L gene
Causes inability for B cells to undergo isotope switching
Produce IgM but not IgG or IgA
