IC8 Flashcards
1
Q
Alkyl substitution may be used to probe the binding site for______
A
size and hydrophobicity
2
Q
Structure extension is adopted to _______
A
explore new interaction outside of the binding site
3
Q
Bioisosteric replacement is carried out using atoms/groups that are believed to have____ physical and chemical properties
A
similar
4
Q
Concern for lead with chiral centres
A
Stereoisomers may display varying biological activity hence need to check!
5
Q
3 key approach to SAR study
A
- Analoguing
- Simplification
- Adding groups
