IC2 Flashcards
Available dosage forms for penicillinase resistant penicillin
IV, IM and Oral
Which Penicillin G is effective against syphilis?
Benzathine
Dosage form for various Penicillin G
IV Potassium
IM Procaine
IM Benzathine
Examples of penicillinase resistant penicillin
Methicillin (Not in use)
Cloxacillin
Oxacillin
Flucloxacillin
Available dosage forms for aminopenicillin
Oral, IV
Property of aminopenicillin that allowed it to penetrate into Gram-negative bacteria via the porins
Aminopenicilliins have additional hydrophilic groups
Dosage form for piperacillin
IV
Which beta lactamase inhibitor binds to beta lactamase and restructures it?
Clavulanate
Which gen is cefuroxime and what is it mainly used against?
2nd gen cephalosporin;
Used against Escherichia coli, Klebsiella, Proteus, Haemophilus influenzae
Which gen of cephalosporin lack activity against LAME species?
1st - 4th gen
Which cephalosporin, when mixed with Ca containing products, can cause Ca precipitates?
Ceftriaxone
Dosage form for carbapenem
IV only
Brand name for imipenem + cilastatin
Tienam
Dosage form for Aztreonam
IM/ IV
When is oral vancomycin used?
CDAD/ more severe antibiotic-associated pseudomembranous colitis
Dosage form for tetracycline
Usually oral; IV avail for doxycycline but not really used
Activity of tetracycline
broad spectrum of Gram-positive, Gram- negative, atypical bacteria and spirochete bacteria
INADEQUATE activity against Pseudomonas aeruginosa and Proteus
How is AG dosed based on?
Lean body mass; Due to low distribution into fatty tissue
Route of elimination for AG
Renal CL
Primary route of elimination for tigecycline
The primary route of elimination is biliary/fecal.
Is AG against Pseudomonas?
Yes
Preferred choice of AG for treatment of Pseudomonas
Tobramycin, used alongside anti- pseudomonal antibiotics.
When is Neomycin contraindicated?
- in the presence of intestinal obstruction/ ulcerative gastrointestinal disease
- history of hypersensitivity to neomycin or other aminoglycosides
