IC2

Question 1

Available dosage forms for penicillinase resistant penicillin

Answer 1

IV, IM and Oral

Question 2

Which Penicillin G is effective against syphilis?

Answer 2

Benzathine

Question 3

Dosage form for various Penicillin G

Answer 3

IV Potassium
IM Procaine
IM Benzathine

Question 4

Examples of penicillinase resistant penicillin

Answer 4

Methicillin (Not in use)
Cloxacillin
Oxacillin
Flucloxacillin

Question 5

Available dosage forms for aminopenicillin

Answer 5

Oral, IV

Question 6

Property of aminopenicillin that allowed it to penetrate into Gram-negative bacteria via the porins

Answer 6

Aminopenicilliins have additional hydrophilic groups

Question 7

Dosage form for piperacillin

Answer 7

IV

Question 8

Which beta lactamase inhibitor binds to beta lactamase and restructures it?

Answer 8

Clavulanate

Question 9

Which gen is cefuroxime and what is it mainly used against?

Answer 9

2nd gen cephalosporin;
Used against Escherichia coli, Klebsiella, Proteus, Haemophilus influenzae

Question 10

Which gen of cephalosporin lack activity against LAME species?

Answer 10

1st - 4th gen

Question 11

Which cephalosporin, when mixed with Ca containing products, can cause Ca precipitates?

Answer 11

Ceftriaxone

Question 11

Dosage form for carbapenem

Answer 11

IV only

Question 12

Brand name for imipenem + cilastatin

Answer 12

Tienam

Question 13

Dosage form for Aztreonam

Answer 13

IM/ IV

Question 14

When is oral vancomycin used?

Answer 14

CDAD/ more severe antibiotic-associated pseudomembranous colitis

Question 15

Dosage form for tetracycline

Answer 15

Usually oral; IV avail for doxycycline but not really used

Question 16

Activity of tetracycline

Answer 16

broad spectrum of Gram-positive, Gram- negative, atypical bacteria and spirochete bacteria

INADEQUATE activity against Pseudomonas aeruginosa and Proteus

Question 17

How is AG dosed based on?

Answer 17

Lean body mass; Due to low distribution into fatty tissue

Question 18

Route of elimination for AG

Answer 18

Renal CL

Question 19

Primary route of elimination for tigecycline

Answer 19

The primary route of elimination is biliary/fecal.

Question 20

Is AG against Pseudomonas?

Answer 20

Yes

Question 21

Preferred choice of AG for treatment of Pseudomonas

Answer 21

Tobramycin, used alongside anti- pseudomonal antibiotics.

Question 22

When is Neomycin contraindicated?

Answer 22

• in the presence of intestinal obstruction/ ulcerative gastrointestinal disease
• history of hypersensitivity to neomycin or other aminoglycosides