IC10

Question 1

What kind of vaccine is Sinovax?

Answer 1

Inactivated vaccine

Question 2

Live attenuated vaccines maintain ____ but loses ______.

Answer 2

antigenicity; pathogenicity

Question 3

Which chemical is used to extract exotoxins and endotoxins?

Answer 3

Formaldehyde

Question 4

Limitation of mRNA vaccine

Answer 4

Ineffective if mRNA does not enter the cell -> viral ptn cannot be expressed

Question 5

Why are antibiotics added to a vaccine? (though not always)

Answer 5

prevent contamination by bacteria during manufacturing

Question 6

Common adjuvant used

Answer 6

Aluminium salt e.g. aluminium phosphate / hydroxide

Question 7

Which vaccine is administered orally?

Answer 7

Rotavirus vacccine

Question 8

Which vaccine is administered intransally?

Answer 8

FluMist (Live, attenuated influenza vaccine)

Question 9

How is antigen content for immunoassay measured?

Answer 9

ELISA

Question 10

How is the potency expressed for live attenuated vaccines?

Answer 10

Potency expressed as PFU/ml (number of infective particle units) or TCID50 (median tissue culture infectious dose)