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Neuro III > Hypothelamus > Flashcards

Hypothelamus Flashcards

1
Q

Three functions

A
  1. Homeostasis

2. Integration for endocrine, autonomic & somatomotor systems

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2
Q

Limbic
Afferent
Efferent

A

Afferent: Median forebrain Bundle (MFB), Fornix, stria termialis

Efferent: MFB, Mamillothalamic tract

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3
Q

Brain stem/ spinal cord

Afferent

A

Afferent: MFB, Dorsal Longitidinal Fasiculus (DLF)
Efferent:

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4
Q

Retina

Afferent

A

Retinohypothalamic Tract

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5
Q

Reticula Sysytem

Efferent

A

Mammillotegmental tract

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6
Q

Autonomic Sytstem

Efferent

A

MFB

DLF

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7
Q

Endocrine SYstems

Efferent

A

Supraopticohypoheseal tract

Tuberoinfundibular tract

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8
Q

Name nuclei in supraopticohypophyseal tract

What do they produce

A

Supraoptic nuclei & paraventricular nuclei

AVP & Oxyctocin

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9
Q

What is the output of the Tuberoinfundibular tract

A

Anterion Pituirtay then hyposeal portal system

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10
Q

Role of sterois on hypthelamic circuts

A

Activation (transient)

Organization (permentate)

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11
Q

When and where do sex steroids make their change in hypothelamus

A

Critical period neonatal and then again at adloescence

VMN and part of POA (preoptic area)

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12
Q

What do presynaptic neuron secrete in reponse to Gonadotropin Releasing Hormone

A

Kisspeptin

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13
Q

Where is the master clock

A

Suprachiasmatic nucleus

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14
Q

Name the other transcription factor involved in the clock

What molecule determins their stability

A

TF: Clock, BMALI, CRT, PER

Casein kinase

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15
Q

Suprachiasmatic Nucleus
Afferent
Efferent

A

Afferent: Retinohypothalamic tract
Efferent: VMN, PVN, LHA. Pineal

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16
Q

Shift work is associated with what disorder

A

Metabolic syndrome

17
Q

Orexigenic

A

Stimulates Feeding

18
Q

Anorexiogenic

A

Supress appetite

19
Q

Name orexigenic peptides

A

Grhein, CKK, Leptin

20
Q

High leptin =

A

High white adipose tissue

21
Q

Low Leptin

A

Activate Orexigenic Pathways

  • Enter BBB at posterior pituater
  • Leptin receptors on Ac neurons that secrete AgRP & NPY
  • Stimulation of PVN
  • Eat more

Inhibit Arexigonic Pathways

  • Low leptin inhibits POMC neurons that produce alpha - MSH
  • AgRP also block alpha-MSH
22
Q

Orexin
Role:
Secreted by
Disease

A

Caloric utilization (brown fat) and slee wake cycle

Lateral Hypothalmic Area

Nacrolepsy

23
Q

Nacrolepsy
Cause
Treatment

A

Neuredegeneration of orexin neurons

Modafinil = Povigil
- increae orexin & dopamine signalining

Neuro III (8 decks)

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