Hypothalamic and anterior pituitary hormones.

Question 1

Tetracosactide is an analogue of what?

What is it used to test?

Answer 1

Tetracocsactide is an analogue of corticotropin (ACTH) and it is used to test adrenocortical function; failure of the plasma cortisol concentration to rise after administration of tetracosactide indicates adrenocortical insufficiency.

Question 2

FSH and LH together, FSH alone (as in follitropin), or chorionic gonadotrophin, are used in the treatment of what? [2]

Answer 2

Infertility in women with proven hypopituitarism or who have not responded to clomifene citrate OR in superovulation treatment for assisted conception.

Question 3

What is clomifene citrate?

Answer 3

It is an anti-oestrogen which induces gonadotrophin release by occupying oestrogen receptors in the hypothalamus, thereby interfering with feedback mechanisms, chorionic gonadotrophin is sometimes used as an adjunct

Question 4

What is growth hormone used to treat?

Answer 4

1. GH deficiency in children and in adults.
2. Prader-Willi syndrome
3. Turner syndrome
4. Chronic renal insufficiency
5. Short children considered small for gestational age at birth, and short stature homeobox-containing gene (SHOX) deficiency.

Question 5

How can short stature homeobox-containing gene (SHOX) deficiency be treated?

Answer 5

Growth Hormone.

Question 6

Growth hormone of human origin (HGH; somatotrophin) has been replaced by what?

Answer 6

Growth hormone of human sequence, somatropin, produced using recombinant DNA technology.

Question 7

What is licensed to treat growth failure in children and adolescents with severe primary insulin-like growth factor-I deficiency?

Answer 7

Mecasermin, a human insulin-like growth factor-I (rhIGF-I).

Question 8

Gonadorelin analogues are indicated in what disease states and conditions?

Answer 8

Endometriosis
Infertility
Breast and Prostate Cancer