Gonadotrophins, drugs affecting

Question 1

What is danazol used to treat? [3]

Answer 1

1. Endometriosis
2. Relief of severe pain and tenderness in benign fibrocytic breast disease where other measures have proved unsatisfactory.
3. Long-term management of hereditary angioedema [unlicensed indication].

Question 2

What are cetrorelix and ganirelix?

Answer 2

LHRH antagonists, which inhibit the release of the gonadotrophins luteinising hormone and follicle stimulating hormone. They are used in the treatment of infertility by assisted reproductive techniques.

Question 3

What are cetrorelix and ganirelix used to treat?

Answer 3

LHRH antagonists, which inhibit the release of the gonadotrophins luteinising hormone and follicle stimulating hormone. They are used in the treatment of infertility by assisted reproductive techniques.

Question 4

Gonadorelin analogues are used in the treatment of [8]

Answer 4

1. Endometriosis
2. Precocious puberty
3. Infertility
4. Male hypersexuality with severe sexual deviation
5. Anaemia due to uterine fibroids (together with iron supplementation)
6. Breast cancer
7. Prostate cancer
8. Before intra-uterine surgery: use of leuprorelin acetate and triptorelin for 3-4 months before surgery reduces the uterine volume, fibroid size and associated bleeding.

Question 5

How is mastalgia normally treated?

Answer 5

Most women will respond to reassurance and reduction in dietary fat; withdrawal or an oral contraceptive or of HRT.

Danazol is licensed for the relief of severe pain and tenderness in benign fibrocystic breast disease which has not responded to other treatment.

Tamoxifen may be a useful adjunct in the treatment of mastalgia.