Glucocorticoid therapy Flashcards
1
Q
When is high glucocorticoid activity in itself of no advantage?
A
When it is NOT accompanied by low mineralcorticoid activity.
For example, the mineralcorticoid activity of fludrocortisone acetate is so high that its anti-inflammatory activity is of no clinical relevance.
2
Q
The relatively high mineralcorticoid activity of hydrocortisone results in what?
A
Fluid retention - making it unsuitable for disease suppression on a long-term basis. IT can however be used for adrenal replacement therapy.
3
Q
Why is prednisolone the corticosteroid most commonly used by mouth for long-term disease suppression?
A
Prednisolone and prednisone have predominatly glucocorticoid activity.
4
Q
What is deflazacort?
A
A derivative of prednisolone with high glucocorticoid activity.
