hypothal pit, Flashcards

1
Q

function of the hypoth

A

Integrates functions that maintain chemical and temperature homeostasis
Functions with the limbic system
Controls the release of hormones from the anterior and posterior pituitary
Synthesizes releasing hormones in cell bodies of neurons.
Two hypothalamic hormones are transported down the axon and stored in the nerve endings of the posterior pituitary
Hormones are released in pulses

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2
Q

hyposphysiotropic hormones

A

releasing and inhibiting hormones

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3
Q

flow of hormones from hypothalamus to ant pit

A
  1. hypophysioisotropic hormones are released from hypothal enter the capillaries
  2. hypothal cap rejoin to form the hypothalamic hypophyseal portal system and go into the ant pituitary
  3. drain into ant pit capillaries
  4. hypophysioisotropic hormones leave the blood across the ant pituitaty and control hormone release
  5. upon stimulation certain pituitary hormones are released
  6. ant pit join to form a vein and hormones are released to body
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4
Q

7 types of hypophysiotropic horomes

A
Thyrotropin-releasing hormone (TRH)
Corticotropin-releasing hormone (CRH)
Gonadotropin-releasing hormone (GnRH)
Growth hormone-releasing hormone (GHRH)
Growth hormone-release inhibiting hormone (GHIH)
Prolactin-releasing factor (PRF)
Prolactin-inhibiting hormone (PIH)
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5
Q

secretion is controlled by

A

Secretion is influenced by emotions and day/night (circadian) rhythm generated by pineal gland secretions
Secretion can be influenced by the metabolic state of the individual

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6
Q

Basophils vs acidophils

A

baso: gonadotropes, corticotropes thyrotrope
acid: lactotrope and somatotropes

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7
Q

receptors of basophils vs acidophils

A

basophils have g protrein receptors

acidophils have JAK/STAT linked cyokine receptors

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8
Q

growth hormone directs mainly to

A

adipose, liver and muscle

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9
Q

excess GH before epiphyseal plate will cause

A

gigantism

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10
Q

excess GH after epiphyseal closure will cause

A

acromegly

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11
Q

reduced childhood GH levels

A

dwarfism

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12
Q

reduced childhood tissue response

A

Laron dwarfism

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13
Q

Thyroid hormone effect of GH
Excess=
defiency =

A

excess=no effect

deficiency- decreased growth

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14
Q

Insulin effect on GH
Hyperinsulinmemia=
deficiency=

A
  1. excess growth.

2. inhibit

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15
Q

sex steroids effect om GH

A

Testosterone and estrogen can stimulate growth

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16
Q

Nuclei in the hypothalamus involved in axons to pos. pituitary

A

Supraoptic and paraventricular

17
Q

pathway of pos pituitary

A

paraventricula or supraoptic nuclei

  1. travel through the pos pit stalk or the hypothamic hypophyseal tract to pos pot.
  2. stimulation and release
18
Q

main 2 hormones of the pos pit

A

ADH
and
oxytocin

19
Q

flow of secretion for ADH

A
nucleus to be transcribed to mRNA 
Preprovasopressin produced in ER
moved to golgi where granules are formed 
grabules moved by microtubules 
neurophysin binds 5 AVP
awaits stimulus for release
20
Q

ADH function

A

Participates in body water regulation (water is lost from lungs, sweat, feces and urine on a daily bas

21
Q

secretion of ADH is stimulated by

A

decrease in blood vol
decrease in bp
pain, fear, trauma , and stress

22
Q

ADH– V2 in the kidneys

A

Decreases water excretion by kidneys

23
Q

ADH– V1 in the kidneys

A

Constricts blood vessels (V1 receptors)- arteriolar smooth muscle

24
Q

ADH– V1B

A

Increases adrenocorticortropin hormone (V1B receptors) secretion from the anterior pituitary

25
Q

increase in osmolarity will cause

A

release of vasopressin

26
Q

oxytocin function

A

Secretion is increased during labor
May also act to facilitate sperm transport in uterus (non-pregnant state)
Increases contraction of smooth muscle of vas deferens