Hyperuricemia

Question 1

Effect of aspirin on uric acid

Answer 1

Low doses hyperuricemia

Niacin also increases uric acid

Question 2

Common treatable causes of hyperuricemia

Answer 2

B12 def, Psoriasis, Lead poisoning, lymphoproliferative disorders

Question 3

When will u do fractional excretion of uric acid

Answer 3

In males less than 30 and premenopausal females with no other causes of hyperuricemia

If >1100mg/day give treatment

Question 4

Cut offs to treat hyperuricemia

Answer 4

Gd 2bc. Males >13 and females >10

May treat also if risk of recurrent urolithiasis or obstructive Uropathy is high

Question 5

Uric acid targets

Answer 5

Gout <6
Asymptomatic hyperuricemia <8

Hyperuricemia of advanced heart failure we don’t treat

Question 6

The only condition arising from hyperuricemia which is difficult to treat

Answer 6

ACUTE uric acid Nephropathy

Question 7

Why statistical definition of hyperuricemia is not used

Answer 7

Because of non normal distribution of uric acid levels in most populations

Question 8

Losartan reduces uric acid by—–%

Answer 8

Upto 20%

Question 9

ARBs which reduce uric acid

Answer 9

Losartan and Irbesartan

Question 10

ARB which may increase uric acid

Answer 10

Candesartan, may be Olme and Valsartan at high doses

Question 11

Cut offs for treating hyperuricemia in renal failure

Answer 11

9,10,12- creat <1.5;Creat >2 and 1.6-2

Question 12

—% of Hyperuricemia remain asymptomatic

Answer 12

2/3rd

Question 13

Why Telmisartan has no role in Uric acid levels

Answer 13

Though it inhibits the URAT 1 but excreted only through liver