Hypertension Medications Flashcards
Dihydropuridine CCBs act where?
Peripheral vasodilation and coronary dilation
Nondihydropyridine CCBs act where?
Heart
What are the Dihydropyridine CCBs?
Amlodipine, Felodipine, and Nifedipine
What are the Non-Dihydropyridine CCBs?
Dilitazem and Verapamil
What are the FDA Indications of CCBs?
HTN, Angina (except Felodipine), AFib, and Cluster HA
What CCBs are approved for AFib?
Dilitazem and Verapamil
What CCBs are approved for Cluster HA?
Verapamil
What ACEs should be taken with food while the others are taken on an empty stomach?
Calan SR and Isoptin SR
What ACE can be spilt in half?
Isoptin SR 240
Are immediate release CCBs (nifedipine) preferred?
NO, they increase risk of hypotension and reflex tachycardia
Are Dilitazem and Verapamil 3A4 Inducers or Inhibitors?
Inhibitors
Since Verapamil and Dilitazem are 3A4 Inhibitors, what drugs do they increase serum concentrations of?
- Atorvastatin, Lovastatin, and Simvastatin
- Amiodarone, Dofetilide
- Uroxatral
- Relpax
- Colchicine
- Budesonide
What are the CI’s of Dihydropyridine CCBs?
- Hypersensitivity
- STEMI = Nifedipine CI
What are the AEs of Dihydropyridine CCBs?
- Peripheral Edema
- Flushing
- HA
- Dizzy
- Hypotension
- Gingival Hyperplasia
What Dihydropyridine CCB has the highest chance of peripheral edema and gingival hyperplasia?
Nifedipine
What are the CI’s of Non-Hydropyridine CCBs?
- Severe Left Ventricular Dysfunction
- Sick Sinus Syndrome = 1st degree AV Block
- SBP <90
What can Non-Hydropyridine CCBs exacerbate?
Any degree of HFrEF due to negative inotropic effect
What are the AEs of Non-Dihydropyridine CCBs?
- Edema
- HA
- Hypotension
- Nausea
- Dizzy
- BRADYCARDIA
- Constipation (V>D)
- Gingival Hyperplasia
Nifedipine Adalat CC is what?
XR tablets, do not crush or chew
Nifedipine Procardia XL is what?
Capsule
Felodipine is what?
XR tablet, extensive 1st pass metabolism
Amlodipine is what?
Tablet, long half life (increased with hepatic dysfunction)
Dilitazem Cardizem is what?
Oral and IV
Dilitazem Tiazac is what?
XR CAPSULE
Verapamil Isoptin SR is what?
Extended Release
What are the indications for Alpha-1-Blockers?
BPH and HTN
What is a concern with non-compliance in Alpha-1-Blockers?
Risk of syncope
What is a condition that can occur with Alpha-1 Blockers and Cataract Surgery?
Floppy Iris Syndrome
What are the AEs of Alpha-1-Blockers?
- Postural Hypotension
- Dizzy
- HA
- Fatigue
- Edema
- Muasthenia
When should the first dose of Alpha-1-Blockers be administered?
At HS, unless ER dose that can be taken in the morning with food
What Alpha-1-Blocker capsule may be taken in the morning with food and the capsule shell may be found within stool?
Cardura XL
What are the dosage forms of Cardura and Hytrin?
Cardura = tablets
Hytrin = capsules
What dosage form of Catapres is TTS?
Transdermal Patches
7 day dosage regimen
What is the indication for Catapres?
HTN
Catapres has DDIs with what drugs?
BB and Tricyclic Antidepressants
What are the AEs of Catapres?
- Hypotension
- CNS Depression: drowsy, fatigue, dizzy
- Nightmare/Vivid Dreams
- Bradycardia
- Rebound HTN/Tachycardia
- Dry Mouth/Constipation
Can you abruptly DC Alpha-2-Agonist Clonidine?
NO
