Hypertension Med Information - Chapter 28 Flashcards
Chlorthalidone dosing
12.5-25 mg daily
Contraindication for thiazides
Hypersensitivity to sulfonamide drugs
Hydrochlorothiazide dosing
12.5-25 mg daily
Thiazide side effects
Decreased potassium, magnesium, and sodium
Increased calcium, UA, LDL, TG, and BG
Photosensitivity
Impotence
Thiazide monitoring
Electrolytes
Renal Function
Thiazide counseling point
Take early in the day to avoid having to get up in the middle of the night to go to the bathroom
Which thiazide is available as an IV?
Chlorothiazide
Nicardipine dosage forms
IV and IR capsule
What is the drug of choice in pregnancy
Nifedipine ER
DHP endings
-pines
Warning for DHP
Hypotension
Warning for Nifedipine IR
Do not use for chronic hypertension or acute BP reduction in non-pregnant patients
Monitoring for DHP
Peripheral Edema
Which DHP is considered safe to used to lower BP in patients with HFrEF
Amlodipine
Side effects of DHP
Peripheral edema
Headache
Flushing
Palpitations
Reflex Tachycardia
Gingival Hyperplasia
Clevidipine dosage form
Injection
Clevidipine contraindication
Allergy to soybeans and eggs
Clevidipine Warnings
Hypotension
Reflex tachycardia
Infections
Clevidipine is a lipid emulsion which means _____
it will be milky
Verapamil biggest side effect
Constipation
Non-DHP side effects
Gingival hyperplasia
Constipation
Do you need a washout when switching from ACE to Entresto
YES
Do you need a washout when switching from ARB to Entresto
NO
ACE BBW
Pregnancy
ARB BBW
Pregnancy
ACE side effects
Angioedema
Hyperkalemia
Hypotension
Renal Impairment
Cough
If a patient develops a cough with an ACE can you switch them to an ARB?
Yes
If a patient develops angioedema with an ACE can you switch them to an ARB?
No
Monitoring for an ACE
BP
Potassium
Renal function
IV ACE
Enalaprilat
Olmesartan warning
Sprue-like enteropathy
Chronic diarrhea with extreme weight loss
Amiloride BBW
Hyperkalmia (K>5.5)
Side effects of K sparing diuretics
Hyperkalemia
Increased SCr
Dizziness
Spironolactone side effects
Gynecomastia
Breast Tenderness
Impotence
Beta blockers BBW
Do not discontinue abruptly - gradually taper the dose to avoid tachycardia and hypotension
Beta Blocker warnings
Use caution in patients with diabetes - beta blocker side effects and hypoglycemia have very simular symptoms
Use caution in patients with Raynaud’s disease - simular symptoms
Non-selective beta blocker warning
Use caution in patients with broncopastic disease
What is the IV to PO conversion of metoprolol tartrate?
1:2.5
How do you switch between metoprolol tartrate and succinate and vice versa?
You have to take the total daily dose and keep it the same.
Example:
- 50mg tartrate BID = 100 mg succinate daily
- 200 succincate daily = 100 tartrate mg BID
Selective Beta blockers side effects
Bradycardia
Hypotension
CNS effects
Impotence
Cold extremities
Nebivolol Contraindication
Liver impairment
Non-selective beta blockers
Propranolol
Nadolol
Non-selective beta blocker contraindications
Asthma
Propranolol is highly lipid soluble so it ________ cross the blood brain barrier
DOES
Other indications for propranolol
Migraine prophylaxis
Essential Tremor
What other condition are non selective beta blockers used for?
Portal hypertension in hepatic disease
Catapress TTS dosage
0.1 mg/24 hours every 7 days
Alpha-2 Adrenergic agonist warning
Do not abruptly stop - rebound hypertension
Side effects for alpha-2 andrenergic agonist
Dry mouth
Fatigue
Dizziness
Somnolence
Constipation
Decreased HR
Hypotension
Impotence
Behavior changes
Other uses for alpha-2 adrenergic agonist
Kapvay - ADHD
Intuniv - ADHD
Methyldopa contraindication
MAO inhibitor concurrent use
Methyldopa warning
Hemolytic anemia
Methyldopa side effects
Drug induced lupus erythematosus
Is methyldopa safe for use in pregnancy
Yes
Hydralazine dosage forms
Tablets
Injection
Hydralazine Warnings
Drug induced lupus erythematosus
Hydralazine side effects
Peripheral edema
Headache
Flushing
Paliptations
Reflex tachycardia
Minoxidil OTC use
Hair growth
Minoxidil BBW
Potent vasodilator - which can lead to pericardial effusion
Minoxidil Side effects
Hair growth
Tachycardia
Fluid Retention