Hypertension Flashcards
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located in the carotids and aorta, sense pressure changes in arterial wall, send impulses via sympathetic motor center
baroreceptors, regulate BP
produces vasoactive substances to maintain low arterial tone, contraction and relaxation
vascular endothelium
thin membrane that lines inside of heart and blood vessels
endothelium
hormone system that regulates BP, fluid and electroylte balance, sodium excretion, ECF volume
renin-angiotensin-aldosterone system RAAS
low BP or sympathetic nervous system trigger kidneys to release
renin, an enzyme
RAAS progression
kidney>renin, liver>angiotensin>AT I formed>angiotensin converting enzyme ACE>AT II forme>aldostrone released by adrenal glands>vasoconstriction>Na+ and water retention>inc BP
hormones made at site of damage, infection that can help inflame/clot contract blood vessels to aid healing but after healing can vasodilate
prostaglandin
endocrine sys and BP: 3 sources
adrenal medulla - epinephrine and norepinephrine
adrenal cortex - aldosterone
posterior pituitary gland - ADH
BP normal
119/79 or less
BP prehypertension
begin 120/80
hypertension stage 1
begin 140/90
hypertension stage 2
begin 160/100
isolated systolic hypertension
SBP over 140 and DBP less than 90
primary or idiopathic hypertension cause
unknown cause 90-95% all cases
elevated BP with a specific cause
secondary hypertension
secondary BP causes
diabetes, cushing’s, thyroid
systemic vascular resistance (SVR)
left ventricle ejects oxy blood through aorta against systemic pressure
high BP or vasoconstriction and SVR
SVR increases as pressure to eject blood into circulation faces increased resistance
peripheral vascular resistance (PVR)
right ventricle ejects deoxy blood into pulmonary artery against pulmonary pressure
BP calculation
BP = CO X PVR
cardiac output (CO) calculation
CO = SV X HR
CO cardiac output definition
volume of blood being pumped by heart in one minute
stroke volume (SV)
amount of blood pumped out of ventricles per beat
alpha and beta drugs ABCD
alpha always constrict, beta always dilate
alpha, beta targets 1 and 2
1 is the heart (only 1 heart) 2 is the lungs (2 lungs)
drug with beta 1 properties will
dilate the heart
drug with beta 2 properties will
act on lungs (2 lungs) and dilate
HTN diagnostics
urinalysis, BUN and creatinine, GFR, lipid profile, uric acid
ambulatory blood pressure monitoring (ABPM)
non-invasive, 24 hour so incorporates daily life, measure BP at preset intervals