Hypertension Flashcards
Name the ACE Inhibitors
Lisinopril
Enalapril
Captopril
Mechanism of ACE inhibitors
Block conversion of Ang1 to Ang2
Keep bradykinin activated
Uses of ACE inhibitors
Cardiac Failure
Hypertension
After AMI
REnal insufficiency
ADR of ACE inhibitors
Severe hypotension
Acute Renal Failure
Hyperkalemia
Angioedema, dry cough
Banned pregnancy
Name AT1 blockers
Valsartan
Losartan
Candesartan
Irbesartan
Telmisartan
MOA of AT1 blockers
Competitively block to prevent Ang2 binding to AT1 receptors
ADR of AT1 blockers
Less or no dry cough
banned pregnancy
Name beta blockers
“Non-selective:
Carvedilol
Propranolol
Pindolol
Cardioselective (Beta-1):
Bisoprolol
Metoprolol
Atenolol”
Uses of Beta blockers
“1. Hypertension
2. Cardiac Failure
3. After AMI
4. Arrythmia
5. Anxiety Disorders”
ADR of Beta blockers
Hypotension
Bradycardia
AV Nodal block
Low Exercise capacity
Bronchoconstriction
CNS e.g. depression
Name Diuretics - thiazides
Hydrochlorothiazide
Indapamide
MOA of thiazides
Inhibit NaCl reabsorption by blocking Na/Cl transporter
Thiazides enhance Ca reabsorption in PCT and distal Convoluted tubule
Uses of thiazides
Hypertension
Congestive HF
Nephrolithiasis
Nephrogenic DI
ADR of thiazides
Hypokalaemic Metabolic Alkalosis
Hyponatremia
Hyperuricaemia
Hyperglycaemia
Hyperlipidaemia
Hypercalcaemia
Name Calcium channel blockers
Nifedipine
Amlodipine
